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Particle

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arunmp's version from 2016-11-13 20:10

Summary

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Particle

Question Answer
Ratio of the photon dose to the particle dose required to produce the same biological effectRBE
Gray multiplied by the relative biological effectiveness(RBE) factor specific for the beam usedGray equivalents (GyE) or cobalt Gray equivalents(CGE)
Unit of ProtonGray Equivalent or cobalt Equivalent
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Based on picture photon versus proton x axis is depth in cm and y axis is dose

 

Question Answer
Irradiate smaller volume of normal tissuesProton
• Energy decreases exponentially with depth in the irradiated tissuesPhoton beam
• Finite rangeproton
• Deposit most of their radiation energy in small areaProtons
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Question Answer
x axisdose in rad *100
y axissurviving fraction
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Brachytherapy Sources and Delivery Devices

Question Answer
32Pbeta Emitter
137Csgamma emiter
192Irgamma emiter
60Cogamma emiter
90Sr/90Ybeta Emitter
186Rebeta Emitter
188Rebeta Emitter
103Pdgamma emiter
106Rubeta Emitter
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HALF LIFE

 

Question Answer
137CsOUR LDR SOURCE 30 YRS
192Ir73 DAYS
60Co5.26 YEARS
103Pd17 DAYS
125Iodine59.4 days
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Beam energy and dmax (cm)

Question Answer
Co-600.5
4 MV1.0
6 MV1.5
10 MV2.5
15 MV3.0
18 MV3.5
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SOURCES

Question Answer
LDR sources137Cs, 192Ir wires/seeds,125I seeds
HDR sources192Ir, 60Co
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Treatment AND %age Survival at 5 years

 

Question Answer
Ext.RT alone36%
Ext.RT+ICBT67%
Single ICBT 60%
2 or more ICBT73%
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DOSE

Question Answer
Para-central dose should be 80-90 Gy
Pelvic sidewall dose should be45-60 Gy.
Local dose to cervix should be21/2 – 3 times the paracervical dose
Surface dose to PROXIMAL vaginal mucosa should be <150 Gy
Surface dose to DISTAL vaginal mucosa should be < 90 Gy
• Rectal dose should be <75 Gy
• Bladder dose should be <80 Gy
2 cm3 of rectum & sigmoid <75 Gy3
 2 cm3 of bladder < 90 Gy3
 High risk CTV & D90 should begreater than the Prescribed dose or (V100 > 90%)
The mean D90 of the GTVBT was120.9 GyEQD2
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