Parkinson Drugs

jozyeb's version from 2016-03-07 09:25



Question Answer
The effectiveness of Levodopa for symptomatic treatment depends onThe presence of some functioning neurons
Levodopa is given with ______, a peripheral Dopa-Decarboxylase inhibitorCarbidopa
Dopamine is derived from what aminoacid?Tyrosine
Which vitamin must a person not take alot of during their treatment with Levodopa?Vitamin B6
You would not want to give a drug that increases dopamine to aSchizophrenic
Dopamine receptor agonist *Dopamine's BRO*
Also treats hyperprolactinemia (dopamine inhibits prolactin) & acromegaly (due to increased hormone growth)

CONTRAINDICATED: Uncontrolled hypertension & sensitivity to ergot alkaloids
used cautiously in patients with MI

Side effects:hypotension, confusion, hallucinations, dizziness, drowsiness <--- alchohol may make it worse

Phenothiazides and haloperidol -----> cause decrease in efficacy of Bromocriptine
Bromocriptine (ergot)
Preferred dopamine receptor agonistPramipexole/Ropinirole (non-ergot)
This drug is given for break through akinesia ("on-off phenomenon")Apomorphine (non-ergot)
Apopmorphine is an emetic and is given withTrimethobenzamide
Irreversible inhibitor of MAO-B; Little potential for hypertensive crisisSelegilline
COMT inhibitors that decrease levels of 3-O-methyldopa (which competes w/ levodopa for CNS entry)Tolcapone (hepatic necrosis)/Entacapone
An antiviral drug that blocks viral uncoating, can cause livedo reticularis (clears randomly) and is thought to increase dopamine release in brainAmantadine
Cocaine related deaths due to hyperthermia are most common inHot Climates