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P&T Drugs Exam 3

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waveurflag's version from 2018-11-18 22:48

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Question Answer
Carbamazepine (Tegretol) Used for: focal, GTC, and mixed MOA: less Na+ influx ADEs: neurosensory, nausea, hyponatremia, rash BBW: APLASTIC ANEMIA, AGRANULOCYTOSIS, SKIN RXNS (CLOP)
Clobazam (Onfi)Used for: LGS MOA: potentiates GABA (WEIGHT BASED: think 30 kg) ADEs: CNS, withdrawal BBW: benzo and opioid COMBO RISK
Eslicarbazepine (Aptiom)Used for: focal MOA: inhibits Na+ ADEs: dizziness, somnolence, n/v, headache, hyponatremia, CYP2C19 inhibitor
Ethosuximide (Zarontin) Used for: FIRST LINE for absence MOA: inhibits Ca++ channels ADEs: nausea and vomiting
Ezogabine (Potiga)Used for: focal MOA: inhibits K+ channels ADEs: QTC prolongation, skin discoloration (blind zebra), urinary retention BBW: VISION LOSS (LONG TERM USE)
Felbamate (Felbatol)Used for: focal MOA: inhibits NMDA and modulates GABA ADEs: insomnia, nausea, headache, weight LOSS (anorexia) BBW: APLASTIC ANEMIA, HEPATIC FAILURE
Gabapentin (Neurontin) Used for: focal (HEMODIALYSIS DOSING) MOA: inhibits alpha-2-delta unit of Ca++ channels ADEs: weight GAIN, aggressive behavior in kids, CNS, withdrawal effects
Lacosamide (Vimpat) Used for: FIRST LINE for focal MOA: inhibits voltage gated Na+ channels ADEs: CNS, GI, may increase PR interval (heart)
Lamotrigine (Lamictal) Used for: focal, GTC, LGSs MOA: inhibits Na+, Ca++, HCN channels and modulates GABA ADEs: CNS, serious skin rashes BBW: RASH
Levitaracetam (Keppra) 😊Used for: FIRST LINE for focal, myoclonic, IGE MOA: prevents neurotransmitter release by binding to SV2A ADEs: CNS effects, but well tolerated!
Oxcarbazepine (Trileptal) Used for: FIRST LINE for focal MOA: inhibits Na+ channels ADEs: CNS, hyponatremia, rash, DON’T GIVE WITH BIRTH CONTROL
Perampanel (Fycompa) Used for: focal, GTC MOA: blocks AMPA-type glutamate receptors ADEs: dizziness, somnolence, headache, and ataxia BBW: PSYCHIATRIC, MOOD, OR PERSONALITY CHANGES
Phenobarbital Used for: GTC, focal, and status epilepticus MOA: prolonging opening of GABA ADEs: SLEEPY drug, somnolence, confusion, behavior problems, hepatotoxicity, TENS (think aztreonam), SJS (macrolides too)
Phenytoin (Dilantin)Used for: FIRST LINE for focal and GTC, used in status epilepticus MOA: inhibits voltage gated Na+ channels ADEs: CNS, gingival hyperplasia, vit D deficiency, bone problems, hypothyroidism, peripheral neuropathy BBW: CARDIOVASCULAR RISK W/RAPID INFUSION
Pregabalin (Lyrica) Used for: focal MOA: alpha-2-GAMMA unit of Ca++ channels (think back to gabapentin and what it targets) ADEs: CNS, weight GAIN, aggressive behavior, more tolerated than gabapentin
Tiagabine (Gabitril)Used for: focal, last line tho MOA: inhibits GABA transporter type 1 (GAT1) ADEs: CNS, GI, new onset seizures
Topiramate (Topamax) Used for: focal and GTC MOA: multiple modes of action ADEs: Kidney stones, weight LOSS, CNS problems, metabolic acidosis, a LOT of drug interactions
Valproic Acid (Depakote) Used for: FIRST LINE for generalized seizures MOA: potentiates GABA, inhibits Na+ and K+ channels ADEs: GI, ALOPECIA AND HAIR CHANGES, a lot of ammonium, liver problems, a LOT of drug interactions BBW: PANCREATITIS, HEPATOTOXICITY, MITOCHONDRIAL DISEASE, FETAL RISK
Vigabatrin (Sabril)Used for: FIRST LINE for baby spasms (Blind Baby) MOA: increases GABA by attacking GABA transaminase ADEs: behavioral disturbances, weight GAIN, edema, aggravates seizures BBW: PERMANENT VISION LOSS
Zonisamide (Zonegran)Used for: FIRST LINE for focal MOA: inhibits zlow Na+ and type T Ca++ channels ADEs: CNS, zedation, weight LOZZ, ZULFA allergy, temperature control, kidney ztones
Lorazepram (Ativan)Preferred IV agent, FIRST line, dose is 0.1 mg/kg
Midazolam (Versed) 0.2 mg/kg IM or 0.15-0.3 mg/kg IN
Diazepam (Valium)Preferred rectal agent, highly lipophilic, 0.15 mg/kg IV
Fosphenytoin (Cerebryx) Used for: status epilepticus MOA: phenytoin prodrug, less adverse effects ADEs: less hypotension, arrhythmias, and infusion site pain BBW: CARDIOVASCULAR RISK WITH RAPID INFUSION
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