Oxygen Containing Reactions

debbiefadoju's version from 2017-06-22 17:10

Section 1

Question Answer
nucleophile ex:anions (CL-), amines, alcohol
nucleophilelewis base
nucleophiledonates electrons to form new bond
nucleophilicity is the opposite ofelectronegativity
nucleophilicity trend on periodic tabledecreases from left to right
nucleophiles make what type of leaving groupbad leaving group
when a nucleophile attacks a weaker nucleophilethe weaker nucleophile will leave
increased nucleophilicity is increasedbasicity
Electron Withdrawing Groups Impact what howIncrease acidity by drawing density away from the acidic proton, increasings its positive charge
Electron Donating Groupsdonate electrons and stabilize positive charge making a molecule more basic
electron donating group examplech3
electron donating groupbasicity
good nucleophilestrong base, bad leaving group
tosylates and meylates are used forprotection of alchols
conversion of alcohol to tosylateprevents the alcohol from acting as an acid or undergoing other other reactions
transesterficationalcohol + methanol (ester) - nucleophilic substitution
lactonewhen alcohol + carboxylic acid are located on same carbon chain, alcohol can attack the carboxylic acid
amideleast reactive because the lone pair on the nitrogen donates electron density
what is stronger? The C-N bond of an amide or C-O bond?C-N bond
lactamunstable in small ring size form
carboxylic acid derivatives undergonucleophillic acyl substitution

Section 2

Question Answer
aldehydes and ketones undergoaddition reactions

Section 3