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Oxidation Of Glucose

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Updated 2009-02-15 23:02

ATP yield from the complete oxidation of glucose

Glycolysis: glucose into pyruvate (in the cytosol)

Reaction SequenceATP yield per glucose
Phosphorylation of glucose-1
Phosphorylation of fructose 6-phosphate-1
Dephosphorylation of 2 molecules of 1,3-BPG+2
Dephosphorylation of 2 molecules of phosphoenolpyruvate+2
2 NADH are formed in the oxidation of 2 molecules of glyceraldehyde 3-phosphate0
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Conversion of pyruvate into acetyl CoA (inside mitochondria)

Reaction SequenceATP yield per glucose
2 NADH are formed0
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Citric Acid Cycle (inside mitochondria)

Reaction SequenceATP yield per glucose
2 molecules of guanosine triphosphate are formed from 2 molecules of succinyl CoA+2
6 NADH are formed in the oxidation of 2 molecules each of isocitrate, α-ketoglutarate, and malate0
2 FADH2 are formed in the oxidation of 2 molecules of succinate0
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Oxidative phosphorylation (inside mitochondria)

Reaction SequenceATP yield per glucose
2 NADH formed in glycolysis; each yields 2 ATP (assuming transport of NADH by the glycerol phosphate shuttle)+4
2 NADH formed in the oxidative decarboxylation of pyruvate; each yields 3 ATP+6
2 FADH2 formed in the citric acid cycle; each yields 2 ATP+4
6 NADH formed in the citric acid cycle; each yields 3 ATP+18
Net Yield Per Glucose+36
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Reference: p.420 of Lubert Stryer's "Biochemistry" 3rd Edition, 1988, W. H. Freeman, New York (ISBN=0-7167-1843-X).

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