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Oncology

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arunmp's version from 2016-12-14 10:49

Section

Oncology
Question Answer
MC Ca in india in malesoral ca
Mc cancer increasing fasstMelanoma
MC cause of death in cainfections leading to heart failure
2nd MC solid tumour in kidsneuroblastoma
Hallmark of malignant transformationanaplasi
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Question Answer
Tumour grade more implymphoma, transitional cellCa, soft tissue sarcoma.
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Prognostic factors

Question Answer
RCCrenal vein invasion
Ca breastLN invol
Soft tissue sarcomagrade
Malignant mesenchymal tumourgrade
HDstaging , histo grading
Burnsextent
Melanomatumour thickness
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Question Answer
Cartilage, elastic arteryresistant to invasion
No metsCNS glioma, BCC
Retrograde mets to ovarykrukenberg
Retro mets to supraclavca pros
Retro mets to adrenalsca lung
Carcinoma invading vesselsRCC, FTC, HCC
Sarcoma by lymphaticsSCARE ME
Ames testmutagenicity-TYPHIMURIUM
Skip metsca bronchus
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Question Answer
LN for secondaries, TBFNAC
LN for lymphomaexcision biopsy
Lesion <5 cmexcisional biopsy
Lesion >5 cmincisional biopsy
Parotid thyroid breastFNAC
Ca breast, FTCfrozen section
Prostate livercore needle
Sentinel LNca vulva, ca penis, melanoma
ExfoliativeCx, bronchus, stomach
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Tumour markers

Question Answer
Granulosa cell tumourinhibin
ChorioCab hCG
Non semin GCTb HCG
Embryonal, teratomab hcg(rare)
MTCcalcitonin
PheoVMA
Dysgerminoma, trophoPLAP
Sclc, neuroblastomaNSE
Lymphoma, ewingsLDH
Endormal sinusAFP
Adeno colonCEA
Breastca 15-3
Pancreas, colon19-9
Ovary125
MMBJ proteins
Most sensitive prosPSA
Sclcbombesin, cea, nse
HCCPIVKA 2
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Chemical oncogens

Question Answer
Polycyclic hydrocarbonssqCC , transitional
ArsenicBCC, ca lung
BenzeneAML
Radioactive stuffLung
Anilinebladder
Nitrosamienseso, gastric
OCP, aflatoxinshepatoma
Vinyl chloride, thorotrastangiosa of liver
ImmunosuppNHL
Alkylating agentsAML, bladder Ca
Wood workersethmoidal sinus adenoca
Nickel industrysq cc
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Question Answer
Promoter of bladdersaccharin
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Promoter of ca breast, endomet, liver
Question Answer
Promoter of clear vagina adenoDES
Promoter of bladder, kidneyphenacetin
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Question Answer
HIVdiffuse large b cell, burkitt
HCVlymphoplasmacytic lymphoma
HHVprimary effusion lymphoma
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Question Answer
HPV 2,7butchers warts
HPV 1,4Simple warts
HTLV 1adult t cell leukemia, tropical spastic paraparesis
HTLV 2HCL, chronic T cell
HTLV 3AIDS
Boca virusbladder
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Question Answer
C raspoint mutation
DNA amplificationTranslocations
Gene amplificationc erb B2
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Question Answer
3-8RCC
15-17m3
KITGIST
K rascolon, lung
H rasbladder
N rasmelanoma
C mycburkitt
N mycneuroblastoma
L mycsclc
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Diet
Question Answer
Beerrectal ca
Smoked fishstomach ca
High fibreintestine
Beefbowel
High fatbreast
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Hormone dependent
Question Answer
TSH dependentPTC
Progesterone depbreast
Estrogen dependometrial
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Androgen dep: prostate

 

Question Answer
CD 44adhesive molecule for vascular spread
Most imp receptors for movt of tumour cellsLaminin
MC site in LNsubcapsular sinus
Cachexia in ca ptTNF a sec by host macrophages n ca cells
Growth factors in invasion TGF a b FGF
S-100neural crest tumours
CD1histocytic origin
CD45leucocyte malignancy
Desminmuscle derived sarcomas
CytokeratinCa, epithelial Ca
Myoglobinrhabdomyosarcoma
Factor 7kaposis, vascular
Thyroglobulinall thy except MTC
GFAPglial tumours
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Question Answer
RCClytic expansile
Thy, Melanoma, pheolytic expansile
RCC secondariespulsating
Osteosa, FTC secondaries, ABCpulsating
Osteoclastomaegg shell crackling
RB, Ewing, Neuroblast, rhabdoBlue round cell
PNETmedulloblastoma, supratentorial, ewings
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Pre malignant
Question Answer
Actinic keratosissqcc of skin
Chronic atrophic gastritisgastric adenoca
C cell hyperplasiaMTC
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Question Answer
Defective dna repairxero pig, atax telan, bloom, fanconi
Mixedphyllodes, wilms,pleo parotid
CALLA, PSAdifferentiation antigen
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Question Answer
Most radiosensitivelymphocytes
TOC is Rx inseminoma, dysgerminoma
TOC is Rx inEwings, neuro, medullo
Radio is NOT effectiveadenoca, non seminoma
Radio is NOT effectiveosteosa, Melanoma, pleo, panc
Emergency radiopancoast
Inverted Y field radioHD
Whole body irradmycosis fungoid, BMT receip
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Question Answer
Neoadj cisplatin/5FUhead and neck
Spontaneous regressneuroblast, MM
NO Spontaneous regressosteosa
Abscopal effectregression of lymphoma after splenectomy
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Immunotherapy

Question Answer
BCGbladder
Levamisolecolorectal ca
IFN amelanoma, lymphoma
Cytokinesrole in RCC, metas melanoma
Corny parvumovarian ca
Immunostimulatorsbcg, corny, leva
Adoptive immunotherapyLAK, IL2
Blood cell separator usedstem cell harvesting
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Regional limb

 

Question Answer
Epithelial pearlSCC
Very slow, highly radioBCC
Fast growing,SxSCC
Inner canthusMC BCC site
Sun exposed areasMC SCC site
Merkel cell cahead n neck,neural crest
Sebaceous caeyelid
Microcystic adnexal caface
Dermatofibrosarcoma protuberanstrunk
Porocarcinomaextremities
MC melanoma site in femaleslower leg
MC melanoma site in malestrunk
Pink fleshy, worst progamelanotic
Breslowmicro tumour invasion
Clarkanatomical level of invasion
RX-melanoma of eyeenucleation
RX-melanoma of toes/fingersdisarticulation
Rx-melanoma of anL canalAPR
Chemo of melanomaDacarbazine
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Question Answer
Ca with max neuro complicationsmalignant melanoma
MelanomaMC pre existing jxn nevus
Melanomanever before puberty
Turban tumourcylindroma of scalp-locally malignant
Marjolins ulcerwell diff SCC in chronic scars n burns-painless-wide ex
Keratoacanthomamolluscum sebaceum
Spontaneous regression of hair follicle-central ulcermoll sebac
Acrochordonmesenchymal skin tumour(what i have)
Tumour of hair folliclebrooke's tumour
Xero pigpremalignant to melanoma
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Question Answer
Commonly turns malignantjunctional melanoma
Children over bumblue nevus(mongolian)
Face of childrenspitz nevus
Turns into lentigo malignahutchinsons melanotic freckle
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Question Answer
Acanthosis nigricansgastric adeno
Necrolytic migratory erythemaglucagonoma
Superficial mig thrombophlebitispanc, lung
Sweet syndromemyloid leukemia
Pagets nippleintraductal
Leser trelatgastric adenoca
Acquired icthyosisHD NHL MM MF
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Question Answer
Kaposisendothelium derived sa
Blue brown plaque--rubbery blue nodulekaposis
MC site of kaposis in non aidslower ex in front of tibia
MC site of kaposis in AIDSpalate(head n neck)
TOC kaposisradio> IFN2 vincris/bleo
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brain tumours

Question Answer
MC site of brain tumour in childinfratentorial(post fossa) > supra
MC site < 1 yrsupratentorial
MC site 1-10 yinfratentorial
MC 1-10juvenile astro, medullo
MC site >10supratentorial
MC >10diffuse astrocytoma
Best prognosis in childcerebellar astrocytoma
MC midline tumourmedulloblastoma
Suprasellar calcifcraniopharyngio
MC supra in childrencraniopharyndio
A/w bitemporal hemi, DIcraniopharyngio
Mets to extracranial sitemedullo
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bt in adults

Question Answer
MC in adultsastrocytoma
MC benign brainmeningioma
MC primary malignant brainGBM
Most malignant in adultsGBM
MC cerebral tumourmets from lungs
MC ca involving nerve plexusmets colon
Parasagitalmeningioma
Frontal lobeoligodendroglioma
4th ventricle in childrenependymomz
Filum terminale in adultsependymoma
MC tumour in cerebellumastrocytoma
MC calcifying bt in adultaoligodendroglioma
Bracket calcificationmeningioma
NF1optic glioma, low astrocytoma
NF2acoustic neuroma, meningioma
Parinaud's syndpinealoma
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Question Answer
Ependymomaintra intra
Neurilemmomaintradural, extramed
Meningioma1/3 intradural, extramed, rem extra extra
MetsMC extra extra
NF, lipoma chordomaextra extra
Overall MC prim SCNF(dumbell tumour)
MC site of meningiothoracic
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Question Answer
RBpremature cells of photoreceptor layer
MC sign of RBleukocoria> esotropia
Ct used for RBvincris
Pseudogliomalow IOT
RBhigh IOT
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Question Answer
SCCepidermoid ca
High rate of mets to neckSCC of tonsils,base of tongue
Low rate of metsbuccal mucosa n palate
Late mets to LNCa lip
Chemo in H n Ncisplatin + 5 FU
MC site of mets in oral lesionlevel 2 LN
MC site of oral caLips > mobile tongue
Ca tonguejugulo omo
Verrucous with buccal caHPV
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salivary

Question Answer
Benign of bone which resembles osteoclastomagiant cell rep granuloma
Warthinshot spot with tc99, benign
Warthinscut section-papillary
All other tumourscold spot with tc99
Infiltrates via neural tissueadenoid cystic ca
MC minor salivary gland tumouradenoid cystic ca
MC site for calculisubmandibular
MC site for minor salivary tumourpalate
MC salivary gland in childrenbenign hemangiomas
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drugs

Question Answer
DOC-CMLimatinib>hydroxyurea
DOC-panc cancerGemcitabine(pyr antag)
DOC-eso cacisplatin
Neurokinin 1 receptor antagAprepitant(for CINV)
Melphalan/TNFrecurrent melanoma,sarcoma
Floxuridineliver mets of ca colon
AlemtuzumabCD 52, resistant CLL
CetuximabEGRF, colon
BevacizumabVEGF colon
Anti metsbosta,fuma,angiostat
Ibritumomaby-90 ,CD20 ,NHL
Tositumomabi 131 NHL
DenileukinONTAK-diph - cut T cell lym
Gemtu,ozogaCD33, refract AML
Flutamidetesto antag-dissem prostate
Leuprolidegnrh analogue-unresectable pros
Aminoglutethemidearom inhib if tamoxifen fails
L asparginaseenzyme useful in cancer
IrinotecanDNA topo I - ovary , lung mets
Fosfestralphos deriv of stilbestr-ca pros
Ftorafuroral 5FU
Dose lim nephrotoctacrolimus
Diarr, rash, raised liverleflunamide
Hemorrhagic cystitiscyclophosphamide
BM, mucosa toxmtx
Skin pig, pulm fibrosisBusulfan
Cardiotoxanthracyclines(doxo,duano)
MUGA scanto asses anthracycline tox
Nephrotoxcisplatin
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drugs 2

Question Answer
IFN alphabest-HCL, CML
IFN bMS
IFN gCGD
Imatinib mesylateTK inhib in CML
GefitinabEGFR TK inhib-adv lung breast
Lapatinabblocks TK adv lung
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drugs 3

Question Answer
1st proteosome inhibbortezomib-MM
Retinoid x receptorBexarotene(Mycosis fungoides)
Inhibits TNF aRevlimib-MM,MDS
Inhibits primary angiogenesisAvastin
Vinka alkaloid for adv SCLCVinorelbine
Excellent CNS penet-melanomaTemozolamide
Enhances radio effectivenessEfaproxiral (RSRI3)
Oral FU for breast,colonCapecitabine
CEA labeled for imagingarcitumomab
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skin

Question Answer
Well diff neoSCC of epidermis, adeno of Thy, HCC
Capsulated malignantFTC, RCC
Non capsulated malignanthemangioma, leiyomyoma of uterus, dermatofibroma
Mets for Caregional LN
Mets for SaLungs
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Paraneoplastic syn

Question Answer
Hypoglycemiahepatoma, mesothelioma
HypercalcemiaSCC of lung, MM, mets from breast,rcc
PolycythemiaRCC,wilms, HCC,VHL,hydroneph
SIADHsclc, brain tumour
Cushings, polymyositis etcsclc
HypogammaCLL, MM, thymoma
Clubbinglung
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soft tissue

Question Answer
MC site for Synovial saknee
Mid thigh mass of 63yr oldmalignant fibrous histiocytoma
MC soft tissue sarcoma in adultmalignant fibrous histiocytoma
Intraop radioretroperi soft tissue sarcoma
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