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Oncogenic proteins

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wudiwida's version from 2018-10-06 03:59

Section

Question Answer
PTENInhibits PI3K/Akt signalling by dephosphorylating PIP3 into PIP2 to prevent inhibition of pro-apoptotic FOXO
RbInhibits G1/S signalling
VHLInhibitor of H1F1-alpha
E-cadherinInhibition of motility
p53Apoptosis due to DNA damage
BRCA1/2Repair dsbreaks in DNA
APC Inhibitor of WNT signalling. Destroys B-catenin so it doesnt act as a transcription factor for cell-cycle progression
CDKN2A/p16inhibitor of cyclin D-CDK4 phosphorylation of Rb
NF-1GAP; negatively regulates Ras
NF-2/Merlincytoskeletal protein for cell to cell junctions and hence signalling
mycTranscription factor for many pro-proliferative genes
VemurafenibBRAF inhibitor
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