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Oncogenes - gene product

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robeyanu's version from 2017-07-24 01:53

Section 1

Question Answer Column 3
ALKreceptor tyrosine kinaseLung adenocarcinoma
BCR-ABLtyrosine kinaseCML, ALL
BCL-2Anti-apoptotic moleculeFollicular and diffuse large B cell lymphomas
BRAFSerine/threoninMelanoma, non-Hodgkin lymphoma, papillary thyroid carcinoma
c-KITcytokine receptorGIST
c-MYCTranscription factorBurkitt lymphoma
Her2/neu (c-erbB2)Receptor tyrosine kinasebreast and gastric carcinoma
JAK 2 Tyrosine kinaseChronic myeloproliferative disorders
KRASGTPasecolon cancer, lung cancer, pancreatic cancer
MYCL1Transcription factorlung tumor
MYCNTranscription factorneuroblastoma
RETReceptor tyrosine kinaseMen 2A, 2B, medullary thyroid cancer
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Tumor Supressor genes

Question Answer Column 3 Column 4
APCNegative regulator of B-catenin/WNT pathwayColorectal cancerCh 5
BRCA1/BRCA2DNA repair proteinBreast, ovarian, pancreaticch 17, 13
CDKN2Ap16, blocks G1-> S phasemelanoma, pancreaticch 9
MEN1meninMEN 1ch 11
NF1neurofibrominNF 1ch 17
NF2Merlin (schwannomin) proteinNF2ch 22
PTENtyrosine phosphatase of PIP3 (eg. protein kinase B [AKT] activationbreast, prostate, endometrial
RbInhibits E2F; blocks G1->Sretinoblastoma, osteosarcomach 13
TP53p53, activates p21, blocks G1-> SLi-fraumeni (sarcoma, breast, leukemia, adrenal gland)ch 17
TSC1Hamartin proteintuberous sclerosis
TSC2Tubers proteintuberous sclerosis
VHLinhibits hypoxia inducible factor 1avHL disease ( hemangioblastoma, angiomatosis, RCC, pheochromocytoma)ch3
WT1Transcription factor that regulates urogenital developmentwilms tumorch 11
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