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Oncogenes

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Updated 2007-03-10 08:02

Oncogenes

Question Answer
abl oncogeneCML
bcl-2 oncogeneFollicular and undifferentiated Lymphomas (inhibits apoptosis)
c-myc oncogeneBurkitt lymphoma
erb-B2 oncogeneBreast OVarian and GASTric Carcinomas
ras oncogeneColon cancer
L-myc oncogeneLung tumor (small cell/oat cell)
N-myc oncogeneNeuroblastoma
ret oncogeneMEN II, MEN III
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Translocations

Question Answer
t(8;14)Burkitt lymphoma c-myc
t(14;18)Follicular lymphoma bcl-2
t(9;22)CML abl
t(11;22)Ewing's Sarcoma
t(11;14)Mantle cell lymphoma
t(15;17)AML (treat=cytarabine)
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Tumor Suppressors

Question Answer
p16Melanoma. 9p
NF1Neurofibromatosis type 1, forces "ras" on. 17q
NF2Neurofibromatosis type 2, 22q, 2-sided (bilateral) acoustic neuromas
p53most human cancers, Li-Fraumerni syndrome. 17p
RbRetinoblastoma, osteosarcoma. 13q
VHLVon Hippel-Lindau, chromosome 3 (3 words in dz)
APCFamilial adenomatous polyposis, chrom 5 (5 letters in "polyp")
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