drshaun's version from 2015-07-18 18:20


Question Answer
what are the cardinal signs of inflammation?heat, redness, swelling, pain, loss of function
3 characteristics of NSAIDSanti-inflammatory, analgesics, anti-pyretic
cheif clinical use for NSAIDstx of musculoskeletal disorders
ADEM of asprinA- rapidly absorbed, D- found in synovial fluid, M-by cytochrome p450, E- renally excreted
adverse effects of aspringastric upset, vertigo, anti-platelet action, Reye's Syndrome
what do you use when anti-inflammatory is not needed?acetaminophen
ADEM of acetaminophenA- rapidly and completely, D- by most fluids, E- hepatic microsomal enzymes, E- all excreted
Adverse rx of acetominophenrash, allergic rxn, hepatotoxcicity
which NSAID is most used as analgesicketorolac
which NSAID has very long half life?Piroxicam
Which NSAID has ocular and oral use?Flurbiprofen
How do NSAIDs work?reversible, competitive inhibitor or COX
COX 1in most tissues, active, necessary for cytoprotection of GI tract
COX 2Enzyme that produces prostanoid mediators, induced in inflammatory cells, important in pain
CelecoxibCOX 2 inhibitor
Which drug has little effect on platelet aggregation with myocardial infarction concerns?Celecoxib
how do you Tx Rheumatoid arthritis?NSAID's and start DMARDS within 3 month
What Antimalarial drug is used to Tx RA?Hydroxychloroquine
How does hydroxychloroquine work?inhibits T cell response, inhibits DNA and RNA synthesis, traps free radicals and inc stress response
What is an Immunosuppresive NSAID?Sulfasalazine and Methotrexate
How does Sulfasalazine work?inhibits leukocyte activation
How does Methotrexate work?increases adenosine release by neutrophils,
which drug is a dihydrofolare reductase inhibitor?Methotrexate
List the Anti- TNFa drugsEtanercept, Infliximab, Adalimumab
which drug is a chimeric monoclonal antibodyInfliximab
Adverse rxns of infliximabUpper Respiratory tract infection, headaches, rash, sinusitus
which drug binds 2 TNFa molecules and inactivates TNF?Etanercept
Adverse rxn from Etanercept?injection site txnm opportunistic infecions, headaches
Adverse rn from Adalimumab?rare leukopenia, rare vasculitis
AbataceptInhibits activation of T cells by blocking B7-1 and B7-2 interaction with CD28
which drug is Used to treat RA when patient is unresponsive to other DMARDsabatacept
which drug is used if anti-TNF therapy has failed?Rituximab
Which drug is taken with methotrexate and treats RZ, ankylosing spondylitis, and psoriatic arthritisAdalimumab