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NIBBS TOX

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nibbs06's version from 2018-01-06 02:54

MECHANISM OF TOX

Question Answer
TTX & DDTMEMBRANE INTERFERENCE (NA+ CHANNEL)
TYLENOLBINDING TO BIOMOLECULES
99% IN RBCs (BOUND TO HEMOGLOBIN)LEAD
REDISTRIBUTES TO BONE - MIMICS CALCIUMLEAD
MAKES P450 A1ATCDD
TCDD TOXICITY EFFECTCHLORACNE
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ELEMENT PROPERTIES

Question Answer
Farmer w/ bronchial issues - cilia damagedsilos fillers disease
MERCURY W/ 90% GI ABSORPTIONORGANIC (METHYL-Hg+)
MERCURY ACCUMULATED IN KIDNEYELEMENTAL Hg0 & INORGANIC Hg2+
ELEMENTS HALF LIFE OF ELIMINATION IS 1-2MONTHSMERCURY (ALL? CONVERTED TO Hg++ in vivo)
ELEMENTS HALF LIFE OF ELIMINATION IS 1-2MONTHS BUT 20-30YRS FROM BONELEAD
ELEMENTS HALF LIFE OF ELIMINATION IS 45MINS-4HRSCO
PX W/ CORONARY ARTERY DISEASE EXERCISINGCAN’T DILATE ARTERIES TO COMPONSATE O2 USE & GET ANGINA
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ELEMENT TOXICITIES

Question Answer
ELEMENTAL TOX ASSOC. W/ CORROSIVE BRONCHITIS & INTESTINAL PNEUMONITISELEMENTAL Hg0
ELEMENTAL TOX ASSOC. W/ THYROID ENLARGEMENT & GINGIVITISELEMENTAL Hg0
ELEMENTAL TOX ASSOC. W/ EXCITABILITY, TREMORSELEMENTAL Hg0
ELEMENTAL TOX ASSOC. W/ MEMORY LOSS, HALLUCINATIONS/DEPRESSION ("MAD HATTER")ELEMENTAL Hg0
ELEMENTAL TOX ASSOC. W/ GI ULCER, BLEEDING/CIRCULATORY SHOCK, NECROSISINORGANIC Hg2+
ELEMENTAL TOX ASSOC. W/ RENAL FAILURE/NECROSIS OF PROX TUBULEINORGANIC Hg2+
ELEMENTAL TOX ASSOC. W/ NEUROPATHYINORGANIC Hg2+
ELEMENTAL TOX ASSOC. W/ NEUROTOXICITY - ATAXIA, VISON/HEARING LOSS, PARESTHESIA, COMA/DEATHORGANIC (METHYL-Hg+)
ELEMENTAL TOX ASSOC. W/ TEROTOGENIC FX - INTERACTS W/ DNA CAUSING BRAIN DEVELOPMENTORGANIC (METHYL-Hg+)
ELEMENTAL TOX ASSOC. W/ WEAKNESS/FATIGUE & CANT FOCUSORGANIC (METHYL-Hg+)
ELEMENTAL METAL ACCUMULATING IN BRAINORGANIC (METHYL-Hg+)
ELEMENTAL METAL FOUND MOSTLY IN KIDNEY BUT ALSO IN FECES(BILE-LIVER), MILK, NAILS, HAIR, SWEATLEAD
ELEMENTAL METAL DISTRIBUTED INTO LIVER & KIDNEYLEAD
METALIC TASTE IN MOUTH W/ MILKY VOMITLEAD (ACUTE XP)
SHOCK SYNDROME (GI FLUID LOSS)LEAD (ACUTE XP)
ANOREXIA & SEVERE ABDOMINAL PAINLEAD (LEAD COLIC)
NEUROMUSCULAR SYNDROME - WRIST DROP, FATIGUELEAD (LEAD PALSY)
HYPOCHROMIC MICROCYTIC ANEMIA - INHIBITION OF HEME PATHWAYLEAD (CHRONIC)
GINGIVAL "LINE", HYPERURICEMIA, PROTEINUREALEAD (CHRONIC)
RENAL FAILURE, METABOLIC ACIDOSIS, LIVER INJURY & COAGULATION DEFECTSIRON
LOSS OF SPHINCTER TONE, COLLAPSE W/ SLIGHT EXERTIONCO
TACHYCARDIA, WEAK PULSE & REDDISH APPEARANCE OF SKINCO
BASOPHILIC STIPPLING IN RBCs (RNA AGGREGATES)LEAD (CHRONIC)
HEMATOPOIETIC TOX, APLASTIC ANEMIA, LEUKEMIABENZENE
HEPATOTOXICITY (METABOLIC ACTIVATION)CCL4
RETINAL TOX, METABOLIC ACIDOSISMETHANOL
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TX

REMOVES SLOW-ELIMINATING/SMALL MW TOXICANTS: HEMODIALYSIS
Question Answer
CYSTEINECHELATORS
PENICILLAMINECHELATORS
BRITISH ANTILEWISITE (BAL)CHELATORS
MERCURY POISONINGSUCCIMER CHELATOR
FIRST LINE CHELATOR FOR KIDSSUCCIMER
"PULLS" LEAD FROM TISSUE TO MEASURE LEAD XPEDTA PROVOCATION TEST
LEAD POISON TREATMENT FOR BLL > 50CHELATION THERAPY - SNGLE OR IN COMBO (EDTA, BAL
D-ALA IN PLASMA IS MEASURED DIAGNOSTICALLYLEAD (CHRONIC)
INITIAL SUPPORTIVE-TREATMENTS FOR LEADMANNITOL & CORTICOSTEROID (DEXAMETHAZONE FOR CEREBRAL EDEMA)
IRON ANTIDOTEDEFEROXAMINE CHELATOR, ASCORBATE
ACUTE CO POISONINGO2
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