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New drugs Hematopoietic system

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alex0624's version from 2016-07-01 00:10

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Question Answer
target: gp2b:3a antagonist (anti-platelete aggregation)abciximab, tirofiban, eptifibatide
Cause severe Neutropenia, thrombocytopnic purpura as side effectTiclopidine
______is a prodrug that is metabolized by ______Clodipine,CYP2c19
A reversible P2Y12 inhibitor that inhibits ADP-induced platelet aggregation. Cangrelor
Potential for autoimmune reaction caracterized by dyspneaCangrelor
It is not a prodrug, and does not require metabolic conversion to an active metabolite (in contrast to clopidogrel); as a result it produces an immediate effect when infusedCangrelor
FibrinolyticsStreptokinase and T-PA
binds circulating plasminogenstreptokinase
bind to fibrinbound plasminogen, more localized actionT-PA(alteplase)
still very important for treatment of coronary occlusion in situations where coronary catherization is not readily availableFibrinolytics
treatment for acute massive pulmonary thromboembolismfibrinolytics
treatment for acute ischemic but should only be initiated within 3 hours after the onset of stroke symptoms, and after exclusion of intracranial hemorrhage fibrinolytics(T-PA and Streptokinase)
anti-fibrinolyticsaminocaproic acid, tranexamic acid
inhibit the function of T-PAtrenaxemic acid and aminocaproic acid
Inactivates clotting factors in intrinsic pathway- thrombin (IIa), IXa, Xaheparin
activates anti thrombin 3Heparin(unfractionated heparin)
heparin(given IV) can be neutralize byProtamine
drug monitoring by aPPTHeparin
Selectively inhibits factor Xa, less effect on thrombin(IIa) Low molecular weight heparin(tinzaparin, enoxaparin, dalteparin)
Prohpylaxis for deep vein thrombosisLMWH(Rivaparin, enoxaparin, dalteparin)
Heparin induced thrombocytopenia treated withprotamine(also fondaparinaux can be given)
inmmediate anticoagulative drug?heparin
Avidly binds antithrombin with high specificity, resulting in inactivation of factor Xa . Does not cross react with pathologic HIT antibodies in most patientsFOndaparinaux
anticoagulant for patients with heparin induced thrombocytopeniaFondaparinaux
Direct thrombin inhibitors. thereby inhibits conversion of fibrinogen to fibrinlepuridin, argatroban, dabigatran
Direct factor Xa inhibitorApixaban and Rivaroxiban
Only oral anticoagulantWarfarin
Decrease the hepatic synthesis of Vit K dependent clotting factors -prothrombin, VII,IX,X as well as the endogenous anticoagulant proteins C and S.- by preventing the gamma carboxylation of glutamate residues of clotting factors (PT is used here)Warfarin
gama carboxylation of glutamate byWarfarin
prevents the regeneration of hydroquinone active formWarfarin
Vitamin K epoxide reductase is inhibited byWarfarin
treatment for warfarin toxicityStop the drug, Vitamin K1
Use for long term anticoagulant(maintainance)given orally.Warfarin(orally)
Treatment for acute Iron toxicityDeferrioxamine(chelating agent)
Pernicious anemia and megaloblastic anemia DOCVitamin B12(cobalamine derivaties)
Administereed in methotrexate toxicityFolic acid
MethotrexateDHFR inhibitor
Treat Neutropenia with cancer drugsfilgrastim(G-CSF), sargramostin(GM-CSF)
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