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Neurotransmitter Changes with Disease

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sws42792's version from 2015-05-25 20:09

Diseases

Question Answer
Alzheimer diseaseDecrease ACh
AnxietyIncrease NE, decrease GABA, 5-HT
DepressionDecrease 5-HT, NE, dopamine
Huntington diseaseDecrease GABA, ACh, increase dopamine
Parkinson diseaseDecrease dopamine, increase 5-HT, ACh
SchizophreniaIncrease dopamine
ManiaIncrease dopamine
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Nerotransmitters

Question Answer
NorepinephrineIncrease in anxiety, decrease in depression
DopamineIncrease in Huntington disease, decrease in Parkinson disease and depression
5-HTDecrease in anxiety and depression
AChIncrease in Parkinson disease, decrease in Alzheimer disease and Huntington
GABADecrease in anxiety and Huntington
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Locations of synthesis

Question Answer
NorepinephrineLocus ceruleus (pons) - stress and panic
DopamineVentral tegmentum and substantia nigra pars compacta (midbrain)
5-HTRaphe nuclei (pons, medulla, midbrain)
AChBasal nucleus of Meynert
GABANucleus accumbens - reward center, pleasure, addiction, fear
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