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Neurology-pathology

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drnieves's version from 2017-06-15 14:47

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Question Answer
ApoE2Decreased risk of Alz
ApoE4Increased risk of Alz
Increased risk of early onsetAPP, presinilin-1, presinilin-2
Most commonly affected in AlzHyppocampus
Alz findingsWidespread cortical atrophy. Narrowing of gyri and widening of sulk. Decreased ACh.
Alz pathologySenile plaques in gray matter; extracellular B amyloid corel may cause amyloid angiopathy= intracranial haemorrhage. Number of tangles correlates with degree of dementia.
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