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Neuro- pharm

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drnieves's version from 2017-06-21 13:52

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Question Answer
TopiramateFor simple, complex and tonic clonic seizures.
Blocks Na ch and increase GABATopiramate
Topiramate ADRSedation , mental dulling, kidney stones, weight loss
TopiramateAlso used for migraine prevention
Alzheimer drugsMemantine, Donepezil, Galantine, rivastigmine, tacrine
Memantine MOANMDA antagonist. Prevent exotoxicity (mediated by Ca)
Memantine ADRDizziness, confusion, hallucinations
Donepeznil, Galantine, Rivastigmine, TacrineAChE I
AChE I ADRNausea, dizziness, insomnia
On-off phenomenonConsequence of progressive nigrostriatal neurodegeneration leading to a decreased therapeutic window for levodopa.
On-off phenomenonUnpredictable
VareniclineACh nicotinic partial agonist a4B2. For nicotine withdrawal.
DantrolenePrevents Ca release from sarcoplasmic reticulum.
Dantrolene usemalignant hyperthermia and neuroleptic malignant syndrome.
Anticholinergic propertiesConfusion, constipation, urinary retention.
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