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MSK-pathology

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drnieves's version from 2017-06-15 14:43

Section

Question Answer
SLERash, joint pain, fever, cytopenias, ulcers, Raynaud phenomenon, photosensitivity.
Libman sacks endocarditisNonbacterial vegetations on both side of valves.
Lupus nephritisType III
SLEnephritic- Diffuse proliferative glomerulonephritis
Nephrotic- MembranousglomerulonephritisSLE
SLEAb- antiphospholipid syndrome
+ vdrl/rprSLE
ANA abSensitive, not specific
Anti-dsDNASpecific, poor px
Antihistones abSensitive for drug induced lupus
Decrease C3, C4, Ch50Immune complex deposition
SLE txNSAIDs, steroids, immunossuppresants, hydroxychloroquine
PolyomyositisProgressive symmetrical muscle weakness. Endomysial inflammation with CD8.
ANA, anti-Jo-1 (anti-histidyl tRNA) ab. Patchy muscle fiber necrosisPolyomyositis
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