What catalyzes the activation (within the cytoplasm) of fatty acids?
Fatty acyl-coA ligase ("acyl-coA synthetase")
Why is fatty acid oxidation termed B-oxidation?
it occurs the sequential removal of 2-carbon units at the B-carbon position of the fatty acyl-coA molecule
What does each round of B-oxidation produce?
one mole of NADH, one mole of FADH2, and one mole of acetyl-coA
Where does B-oxidation occur?
In the cytosol (mitochondria)
What the B-oxidation require?
The equivalent of 2 ATP molecules
Why is carnitine important in B-oxidation?
Allows fatty acyl-coA to be transported into the mictochondria
Why is there a metabolic difference between the oxidation of saturated vs. unsaturated fats?
Unsaturated fats produce less energy because there double bond has to be moved from cis to trans by enoyl-coA isomerase which required two ATP. Unsaturated fatty acids provide less energy because they are more highly reduced.
How does B-oxidation of odd-numbered fatty acids proceed?
By the same reaction steps as even numbered until the final three carbons are reached
What are the final three carbons of odd numbered fatty acids called?
What is proprionoyl coa converted to in odd B-oxidation?
succinyl coA through a multistep ATP-dependent pathway. Succinyl CoA can then enter the TCA cycle.