Misc Repro Drugs

veranellasel's version from 2015-06-17 23:34

Section 1

Question Answer
anastrozole / exmestanearomatase inhibitors used in post menopausal women w/ breast cancer (decreases estrogen)
side effects of anastrozole / exemestaneincreased risk of osteoporosis and fractures
clomiphene MOApartial agonist (hence antagonist) at estrogen receptors in hypothalamus; stops normal feedback inhibition of hypothalamus by estrogen to increase LH and FSH secretion
clomiphene usetreat infertility, PCOS, anovulation
side effects of clomiphenelike menopause since it's an estrogen blocker: hot flashes, ovarian enlargement (increased follicle development by FSH), multiple pregnancies and visiual distrubances and may increase ovarian cancer risk
danazol MOApartial androgen agonist; synthetic androgen
why do we use danazolendometriosis and hereditary angioedema
side effects of danazolwt gain, edema, acne, hirsutism, masculinization, and decreased HDL levels and hepatotoxicity
terbutaline MOAbeta agonist that relaxes uterus
why do we use terbutaline?delay delivery

Section 2

Question Answer
salbutamol, ritodrine and terbutaline are beta agonists; used for relaxing SM of uterus
Side effects of beta agonists:increased HR, hypokalemia, hypotension, hyperglycemia in mom and baby and pul edema
Nifedipine is a blocks voltage gated L channel to relax SM
MgSO4 is used for stopping seizures w/ ecclampsia and competes at Ca2+ channels to relax SM
Why do we use NSAIDs to delay delivery?stops COX enzyme and blocks PGF2 and PGE2

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