Microbiology Associations (TQ)

jnaterman's version from 2016-05-21 23:42

Bacteria High Yield 1

Question Answer
Reactive arthritis (2)Chlamydia trachomatis, C. jejuni, other GI infections
Guillain-barre Syndrome C. jejuni
Painless Chancre, Palmo-plantar rash, Gummas, General Paresis, Tabes dorsalis & Jarisch-Herxheimer Reaction Treponema pallidum
Hutchinson’s Triad Congenital syphillis
ChancroidHaemophilus ducreyi (Chancre = painless, chancroid = painful)
Donovanosis Klebsiella granulomatis
Trachoma, Lymphogranuloma venereum, Adult / Neonatal inclusion conjunctivitis Chlamydia trachomatis
PsittacosisChlamydophila psittacci (exotic birds, esp. parrots)
Fitz-Hugh-Curtis SyndromeNeisseria Gonorrhoeae
Disseminated Gonococcal Infection (DGI)Neisseria Gonorrhoeae w/ bacteremic spread


Question Answer
Waterhouse-Friderichsen Syndrome Neisseria Meningitidis
“Sulfur granules” or Calcium pyrophosphate crystalsActinomycosis
“Currant-jelly” sputum Klebsiella pneumoniae
Wool sortersBacillus anthracis (cutaneous anthrax)
Verruga Peruana Bartonella bacilliformis
Q-Fever Coxiella burnetii
Pontiac FeverLegionella (Legionnaire's disease)
Pseudomembranous colitis/toxic megacolonClostridium difficile
Gaseous gangrene, myonecrosisClostridium perfringens

Bacteria High Yield 1

Question Answer
Flaccid paralysis, floppy baby syndromeClostridium botulim
Petechial rashNeisseria Meningitidis
Intra-abdominal infections #1 causeBacteroides fragilis
Typhoid feverSalmonella typhi
Whooping coughBordetella pertussis
Epiglottitis "cherry red" in childrenHaemophilus influenzae (Typeable)
TularemiaFrancisella Tularensis (can be ulceroglandular or oculogladular)
Bubonic Plague “Black Death”Yersinia pestis


Question Answer
Cat stratchBartonella henselae
Trench feverBartonella quintana
Rocky Mountain Spotted FeverRickettsia rickettsii (Rikishi's ass)
Lyme DiseaseBorrelia burgdorferi
Hemorrhagic pleural effusions, mediastinal widening, hemorrhagic meningitisInhalation anthrax
PAS stain macrophage inclusions, gram positive bacillus, unable to cultureWhipple's disease
GBSC. jejuni
Winter outbreaksNorovirus
Traveler's DiarrheaETEC
Bacillary dysenteryShigella dysentariae

Protozoa High Yield

Question Answer
Romana's sign (swelling around eye)Trypanosoma cruzi
Chagas diseaseTrypanosoma cruzi
Hemoflaggellates (2)Trypanosomes, Leishmania
Waterborne, fatty diarrheaGiardia lamblia
Dysentary, liver abscessEntamoeba histolytica
Acid fast, watery diarrheaCryptosporidium
Ring enhancing lesions, heretophile negative monoToxoplasma gondii
Cribriform plate, meningoencephalitisNaegleria fowleri
Cyclic fever, anemia, splenomegalyPlasmodium
Hepatosplenomegaly, ulcer skin lesionLeishmania donovani
Strawberry cervixTrichomonas vaginalis
African sleeping sickness, malaria-like diseaseTrypanosoma brucei

Helminths High Yield

Question Answer
Anal pruritis, scotch tape testEnterobius vermicularis (pinworm)
Obstructs intestine, biggest roundwormAscaris lumbricoides
Epigastric pain, autoinfectionStrongyloides stercoralis
Microcytic, hypochromic anemiaAncylostoma duodenale, Necator americanus (hookworms)
River blindness, black nodules/skinOnchocerca volvulus
African eye wormLoa Loa
Elephantiasis, lymphedemaWuchereria bancrofti
Visceral larva migransToxocara canis
Neurocysticercosis, seizuresTaenia solium
Pernicious megaloblastic anemiaDiphyllobothrium latum
Cysts, anaphylaxis if removedEchinococcus granulosus
Bladder carcinoma w/ painless hematuriaScistoma haematobium
Swimmer's itch (purutic dermatitis)Avian schistosomes


Ticks (6)Lyme Disease, RMSF, Erlichiosis, Tularemia, Babesiosis, Q-fever
Flies (2)Trachoma (C. trachomatis), Tularemia (F. tularensis)
Fleas, RatsBubonic plague (Y. pestis)
Rabbits, small mammals Tularemia (F. tularensis)
CatsCat-scratch disease; Peliosis hepatis, Bacillary angiomatosis; Endocarditis (Bartonella henselae)
Body Louse Trench Fever; Bacillary angiomatosis; Endocarditis (Bartonella quintana)
Sheep Anthrax (B. anthracis)
Cattle, Goats, Sheep (2) Brucella spp., C. burnetti (Q-fever)
Bodies of Water (3)Vibrio vulnificus, Aeromonas hydrophila, Legionella
Potential agents of Bioterrorism (4)B. anthracis, Y. pestis, F. tularensis, C. burnetti (Q-fever)


S. aureus (3)Enterotoxin, TSST-1, Exfoliative toxin
S. pyogenes (2)Pyrogenic exotoxin, Streptolysin O
C. diphtheriaeExotoxin
L. monocytogenesListerialysin O
B. anthracisLF, EF, PA
B. cereusHL, HS enterotoxins
C. botulinumNeurotoxin
C. tetaniTetanospasmin
C. perfringensEnterotoxin, Lecithinase alpha toxin
C. difficileCytotoxin
ETECHL, HS enterotoxins
EHECShiga-like toxin
ShigellaShiga toxin
V. choleraeCholera toxin
C. jejuniEnterotoxin
P. aeruginosaExotoxin A
B. pertussisPertussis toxin

Important Pathogenic Factors and Enzymes

Question Answer
M Protein - 1Antiphag
Group A strep
A Protein - 1Binds FC of IgG to inhibit phag/opsonization
Staph aureus
Lipoteichoic Acid - 1Attachment of host cells
All gram positive bacteria
All pili - 1Attachment
Mainly in gram negatives
Which pili is antiphagocytic with antigenic variation?N. gonorrhea
Hyaluronidase -1 Hydrolysis of ground substance
Group A strep
Collagenase - 2Clostridium perfringens, Prevotella melaninogenica
Urease - 5Increases pH and contributes to ammonia stuvite stones
Proteus, Ureaplasma, Nocardia, Klebsiella, Cryptococcus, H. pylori
Lecithinase -1Destroy cell membranes
C. perfringens
Heparinase - 1Thromboplebitis
Catalase - 5 main. 1 groupDestroys H2O2; probem for CGD patients
Mainly in Staph, Pseudomonas, Aspergillus, Candida, and E. coli infections.
Most anaerobes lack catalase
IgA Protease - 3Destroys IGA and promote mucosal colonization
Neisseria, Haemophilus, and Strep penumo
Coagulase - 2Produces fibrin clot
Staph aureus and Y. pestis

Oncogenic Microbes


Question Answer
EBV (4)Burkitt lymphoma, Hodgkin lymphoma, nasopharyngeal carcinoma, CNS lymphoma (in immunocompromised patients)
HBV, HCVHepatocellular carcinoma
HHV-8 (2)Kaposi sarcoma, body cavity fluid B-cell lymphoma
HPV (3)Cervical and penile/anal carcinoma (16, 18), head and neck or throat cancer
H. pylori (2)Gastric adenocarcinoma and MALT lymphoma
HTLV-1Adult T-cell leukemia/lymphoma (ATLL)
Liver fluke (Clonorchis sinensis)Cholangiocarcinoma
Schistosoma haematobiumBladder cancer (squamous cell)


Question Answer
Airborne + Contact isolationSmallpox
Contact isolation (gowns+gloves) (4)MRSA, VRE, C. Diff and MDR Gram Negative pathogens.
Airborne isolation (N-95 filters and Neg airflow) (3)TB, Varicella, and Measles
Droplet isolation (regular mask with face shield)Most respiratory viruses (e.g. Influenza, Adenovirus, RSV, Parainfluenza, Pertussis etc.)
When should face masks be worn?Potential for splash/spray or exposure to respiratory droplet/secretions