Micro - Take 2 - Nessie Monster

lunalovegood's version from 2016-02-05 03:16


Nessie Monster is REAL
Question Answer
Aerobic or non?aerobic
Gram ___negative
Shape?cocci (usually seen in pairs)
Produce acid by ___, not by fermentationoxidation
___ different species20 (10 human, 10 other animal)
T/F - N gonorrhea and N meningitidis are important genera.True
Good way to grow it?no
___ are associated with virulence.pili (adhesion)
The ___ pili are pathogenic.long (long penis gives you gonorrhea)
Important for variation, adherence, entry by nucleating actin which modifies the cytoskeleton and protection from host.Porins (protein 1-5 or Pro, Opa, Opc)


Wake me up, before you GONORRHEA
Question Answer
Fastidious or non?fastidious
Sensitive to ____drying
Needs additional ___ for isolationCO2
Temperature?35-36 degrees
Grown on _________ agarchocolate (use chocolate and get Gonorrhea)
Protects bacteria from the hostloosely adherent capsular-like structure
Capsular-like structure contains?high MW polyphosphate
Favorite places?cervix, uterus, fallopian tubes and urethra
Other places?mouth, throat, eyes, anus
This subtype looks like gonorrhoeae.N kochii (misdiagnosis common - acid production test will identify as gono, similar colony morph to N meningitidis, produces hydroxyprolylaminopetidase like Gono)
______ is only carb oxidized to acid.Glucose
T/F - In US like 20mil new STD infections per year.True (YUCK! cost 16bil ! )
1728-1793 The authority on venereal diseases.John Hunter (his John hunts STDs)
What did John Hunter think?2 diseases could not exist simultaneous on same organ (inoculated himself, got syphilis and gono, treated with mercy and cauterization)
Bicuspids, cuspids, incisors and molars!Oh my! John Hunter wrote first dental anatomy book
Divides by?binary fission
Divides every?20-30 minutes
_________ dischargeexudate/mucopurulent
Incubation period?3-5 days (lit. 1-30 days)
T/F - Passes through cells of mucosa to subepithelial CT and with help of cytokines elicit an inflamm response primarily consisting of PMNs.True
Use ___ for growth.transferrin-bound and lacoferrin-bound iron
T/F - Damages tissue.True
Antiphagocytic capsule?possibly
Antibodies are ___opsonic (try to prevent pili attachment)
Name 3 porin proteins.Opa, Opc, Rmp
Has a protease that cleaves ___IgA (the cleaved fragments can block other Igs from reacting)
T/F - Blebs are pathogenic and can cause reactions in our body.True
Bacteria come in via ___ .endocytosis
T/F - Bacteria can be in cell, can go through BM, can survive ingestion, can release more cytokines and can cause cells to break apart.True
N. gonorrhoeae induces host cell ___apoptosis (can cause a lot of damage quickly!)
T/F - During infection, the pore forming outer membrane protein PorB is translocated to the cytoplasmic membrane of host cells where it forms a regulate pore.True (In infected cells, PorB is efficiently targeted to and intergrated into the mitochondrial membranes causing membrane potential breakdown, release of cytochrome c leading to caspase activation and apoptosis. )
>13% are resistant to ___fluoroquinolones
T/F - 33% were resistant to penicillin, tetracycline, and ciprofloxacin.True
Single exposure from woman ____% likely to acquire20-25%
Single exposure from man ___% likely to acquire.40-70%
Males ___% asymptomatic10-15%
Females _________% asymptomatic50% (with cervical infections)
Name 4 means of diagnosis.Culture, Nucleic acid amplification, Immunofluorescence, Serology


Oral Gonorrhea
Question Answer
Sharply localized white or yellow-white patch.could be oral gonorrhea infection
Generalized gray, adherent membrane that sloughs, leaving red area with bleeding pointscould be oral gonorrhea infections
Inflamed gingiva?yes
May see lesions on ___ and ___tongue, soft palate
Whewy! What's that SMELL?!fetid odor
Can lead to...widespread lesions in other organs
Fever ___ present.usually


Question Answer
Aerobic or non?aerobic
Gram ___negative
Fresh isolates are encapsulated?yes
Susceptible to ____ and low ___drying, pH
_________ serogroups12 (grouped by capsular antigen)
Serogroups A, B, and C account for > ___% of meningococcal disease.90%
Catalase? Positive
Oxidizes ___ to acid.glucose AND maltose (yellow)
Present in ___ of healthy persons.nasopharynx
N. Meningitidis causes ___% of cases of meningitis.59%
ABSENCE OF ___antibodies
Has ___ which helps to avoid phagocytosis.IgA protease
Has the endotoxin ___LOS
Capsule?Of course
Transmission?respiratory (often by carriers)
T/F - Adhere by pili which allows movement across the blood-brain barrier without destroying the intercellular tight junctions.True (allows for pr conc to maintain itself. Can cause the same type of damage we saw with N Gono)
Transverse mucosa via ___phagocytic vacuoles (or other damaged epithelium)
T/F - Causes vascular damage, thrombosis, DICTrue
Stimulates ___ that increase vascular permeability and that of blood-brain barrier.cytokines
Suppresses cytokines from ___ that are related to chemotaxis.PMNs
Up to _________% of pop may be carriers.10%
Fever, pharyngitis, macular rash, petechial eruption, ecchymosis, headache, stiff neck, lesions in skin meninges joints or lung.clinical disease
___-___% of cases are fatal.10-14%
___-___% of cases have permanent hearing loss, mental retardation, loss of limbs, etc.11-19%
US vaccines usually protect against serogroups _________, _________ and _________.B, C, and Y
Are children 2-10 with cochlear implants a high risk group?yes
Are persons with damaged/removed spleens a high risk group?yes

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