Micro 13

jennraq2u's version from 2015-10-04 01:05


Question Answer
obligatory intracellular parsitesviruses=require living host cells 2 multiply. (Property shared by bacteria 2)
host rangespectrum of host cells virus can infect
bacteriophages/phagesviursus that can infect bacteriA
virioncomplete/fully devp'd infectious viral particle=nucleic acid+protein coat
capsidprotein coat that protects virus' nucleic acid
envelopeIn SOME viruses;
spikescarb-protein complexes projecting from surface of envelope; vehicle for attch
complex viruses(ie. bacteriophage/poxviruses)
genus namessuffix-virus
family namesend in -viridae
order namesend in -ales
viral speciesgroup of viruses sharing same genetic info/ ecological niche(host range).
cytopathic effect (CPE)caused by viruses infecting monlayer of cell culture->detioriates as virus multiplys
primary cell lineshuman tissue cells that grow for only a few generations in vitro.
diploid cell lineseukaryotic cells grown in vitro
Attachmentphage attaches by tail fibers to host cell
Penetrationphage lysozyme opens cell wall; tail sheath contracts to force tail core and DNA into cell(hyperdermic needle)
Biosynthesis production of phage DNA and proteins
Maturationassembly of phage particles
Releasephage lysozyme breaks cell wall
eclipse periodperiod during
Lytic cycle (Results)Phage causes lysis and death of host cell
lysogenyphage remains latent
phage conversionhost cell exhibits new properties (ie. toxins/Strep/TSS)
specialized transductiononly certain bacterial genes are transferred to a phage coat
Lysogenic cycle(Results)Prophage DNA incorporated in host DNA*Phage conversion* Specialized transduction
Mult Animal Virus (Attachment)viruses attach to cell membrane
Mult Animal Virus (Penetration)by endocytosis or fusion
Mult Animal Virus (Uncoating)by viral or host enzymes
Mult Animal Virus (Biosynthesis)production of nucleic acid and proteins
Mult Animal Virus (Maturation)nucleic acid and capsid proteins assemble
Mult Animal Virus (Release)by budding (enveloped viruses) or rupture
receptor-mediated endocytosistype of pinocytosis; molecules bound 2 proteins on plasma membrane R taken in by infolding of membrane
fusionviral envelope fuses w/ plasma membrane & releases capisid into cell's cytoplasm (ie. HIV)
uncoatingseperation of viral nucleic acid from protein coat once virion is enclosed w/n vesicle
Transformed cells have increased growth, loss of contact inhibition, tumor-specific transplant antigens, and T antigens
sense strand (or + strand)Viral RNA that can act as mRNA
antisense strand (-strand) Viral RNA that cannot act as mRNA
PrionsProteinaceous infectious particle; Inherited and transmissible by ingestion, transplant, and surgical instruments
Plant virusesenter through wounds or via insects
Viroidsinfectious RNA; e.g., potato spindle tuber disease
ParvoviridaeSingle-stranded DNA, nonenveloped viruses: Fifth disease *Anemia in immunocompromised patients
AdenoviridaeDouble-stranded DNA, nonenveloped viruses;Respiratory infections in humans *Tumors in animals
PapovaviridaeDouble-stranded DNA, nonenveloped viruses; Papillomavirus/Polyomavirus
PoxviridaeDouble-stranded DNA, enveloped viruses->Orthopoxvirus*Molluscipoxvirus*Smallpox, Molluscum contagiosum, Cowpox
HerpesviridaeDouble-stranded DNA, enveloped viruses; Some herpesviruses can remain latent in host cells
HepadnaviridaeDouble-stranded DNA, enveloped viruses ;Hepatitis B virus*Use reverse transcriptase
PicornaviridaeSingle-stranded RNA, + strand, nonenveloped;
CaliciviridaeSingle-stranded RNA, + strand, nonenveloped
reverse transcriptaseuses viral RNA as template to produce complementary dsDNA
provirusunlike a prohophage; provirus NEVER leaves chromosome; protected from immune system
oncogenescancer causing alterations to cellular DNA r/t pt of genome
oncogenic virusesvirus capable of inducing tumors in animals
tumor -specific transplantation antigen (TSTA)viral antigen on surface of a transformed cell
T antigenantigen in nucleus of a tumor cell