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Mechinsims of action usmle- psychiatry and reproductive

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summerahmed's version from 2015-07-20 04:48

psychiatry

Question Answer
haloperidoltypical antipsychotic. block dopamine D2 receptor and thus increse cAMP. high potency. for schizophrenia positive symptoms,acute mania and tourette syndrome
triflupirazinetypical antipsychotic. block dopamine D2 receptor and thus increse cAMP. high potency. for schizophrenia positive symptoms,acute mania and tourette syndrome
fluphenazinetypical antipsychotic. block dopamine D2 receptor and thus increse cAMP. high potency. for schizophrenia positive symptoms,acute mania and tourette syndrome
chlorpromazinetypical antipsychotic. block dopamine D2 receptor and thus increse cAMP. weak potency. for schizophrenia positive symptoms,acute mania and tourette syndrone
olanzepinenot completely understood varied effects on 5HT2 dopamine, alpha and H1 receptors
clozapinenot completely understood varied effects on 5HT2 dopamine, alpha and H1 receptors
queotapinenot completely understood varied effects on 5HT2 dopamine, alpha and H1 receptors
respiridonenot completely understood varied effects on 5HT2 dopamine, alpha and H1 receptors
aripiprazolenot completely understood varied effects on 5HT2 dopamine, alpha and H1 receptors
ziprasidonenot completely understood varied effects on 5HT2 dopamine, alpha and H1 receptors
lithiumnot established possibly related to inhibition of phosphoinositol cascade
Buspironestimulate 5HTa1 receptors
fluxetine5HT specific reuptake inhibitor SSRI
paroxitine5HT specific reuptake inhibitor SSRI
citalopram5HT specific reuptake inhibitor SSRI
sertraline5HT specific reuptake inhibitor SSRI
venlafaxine5HT and NE reuptake inhibitors SNRI
duloxetine5HT and NE reuptake inhibitors SNRI
amytryptalineTCA block reuptake of 5HT and NE
nortriptalineTCA block reuptake of 5HT and NE
imityptalineTCA block reuptake of 5HT and NE
desipramineTCA block reuptake of 5HT and NE
clomipramineTCA block reuptake of 5HT and NE
doxipenTCA block reuptake of 5HT and NE
amoxapineTCA block reuptake of 5HT and NE
phenalzinenon selectine MAO inhibitors. increase levels of amine transmitters NE 5HT and DA
Tranylcyprominenon selectine MAO inhibitors. increase levels of amine transmitters NE 5HT and DA
Isocarboxazidenon selectine MAO inhibitors. increase levels of amine transmitters NE 5HT and DA
seligilinenon selectine MAO inhibitors. increase levels of amine transmitters NE 5HT and DA. used in ttt of parkinsons
Bupropionsmoking cessation by increasing the NE nd the DA by an unknown mechanism
Mirtazipinealpha2 antagonist ( increase the release of NE and 5HT) and potent 5HT2 and 5HT3 receptor antagonist
Trazadoneprimarily blocks the 5HT2 and alpha1 adrenergic receptors for insomnia and high doses for antidepressant effects
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reproductive :

Question Answer
loperulideGnRH analog with agonist properties when used in a pulsatile manner and antagonist properties when used continuously ( down regulates the GnRH receptors on the pituitary so decreases the FSH and LH)
ethinyl estradiolbind to estrogen receptors, for hypogonadism or ovarian failure, menestrual abnormalities, HRT, in men with androgen dependant prostate cancer
Diethylsalbesterolbind to estrogen receptors, for hypogonadism or ovarian failure, menestrual abnormalities, HRT, in men with androgen dependant prostate cancer
mestranolbind to estrogen receptors, for hypogonadism or ovarian failure, menestrual abnormalities, HRT, in men with androgen dependant prostate cancer
clomipheneselective estrogen receptor modulator.estrogen antagonist on hypothalmus, prevents the normal feedback inhibition and increase the release of LH and FSH from pituitarywhich stimulates ovulation for ttt of PCO
tamoxifenSERM antagonist on the breast and agonist on the bone and the uterus
raloxifenSERM antagonist on the breast and uterus and agonist at the bone
anstrazolearomatase inhibitors block the conversion of andrtestandione to estrone. used in postmenopausal women with ER+ve breast cancer
exemestanearomatase inhibitors block the conversion of andrtestandione to estrone. used in postmenopausal women with ER+ve breast cancer
progestinbind to progesterone receptor. decreases the growth and increases the vascularization of the endometrium
mefipristoneRU-486, compettive inhibition on progesterone on its receptors
terbutalinebeta 2 agonist relaxes the uterus and decreases the contraction frequencies during labour
ritodrinebeta 2 agonist relaxes the uterus and decreases the contraction frequencies during labour
testosterone, methyltestosteroneagonists on the androgen receptors.
finastride5 alpha reductase inhibitor, decreases the conversion of testosterone to DHT 9 dihydrotestosterone) given in ptns with BPH and male pattern baldness
Flutamidenonsteroidal competitive inhibitors inhibitors in androgen receptors
Ketoconazoleinhibit 17, 20 desmolase which inhibits the conversion of cholesterol to testosterone
spironolactone inhibit 17, 20 desmolase and 17 alpha hydroxylase which inhibits the conversion of cholesterol to testosterone
Tamsulosinalpha1 antagonist used for ttt BPH selective for alpha1A/1D receptors found in prostate ns the vascular alpha1B receptor
Sildenafil, Vardenafil, tadalafilinhibitors of PDE-5 Inhibitors increases the cGMP and the smooth ms relaxation in corpus cavernosum so increases the blood flow leading to penile erection
minoxidildirect arteriolar vasodilator given in androgenic alopecia and in sever refractory hypertension
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