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Mechanisms, Classes, Structures

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munsele's version from 2016-06-28 15:48

Section 1

Question Answer
Beta-lactams/monobactamsInhibits cell wall synthesis, binds PBP - cidal
QuinolonesBinds to topo 4 and inhibits DNA gyrase cause breakage - cidal
TetracyclineReversibly binds 30s ribosomal subunit - static
SulfonamidesInhibits folate pathway enzymes - cidal with trimethoprim
MacrolidesBinds to 50s - static
GlycopeptidesInhibits cell wall synthesis by blocking peptidoglycan polymerization - cidal
Lipopeptides Binds to cell membrane causing rapid depolarization and inhibits RNA/DNA synthesis - cidal
OxazolidinonesBinds to 23s on 50s subunit inhibiting translation and synthesis - static
LincosamideReversibly binds to the 50s - static
Anti-protozoal/anti-bacterialAffects structure of DNA and causes strand breakage
AminoglycosidesBinds to the 30s and 50s - concentration dependent
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Section 2

Question Answer
Polyene antifungalsbinds to ergosterol which causes ion channels to form (leaky)
Uracil blockersPenetrates fungal cell wall to compete with uracil inhibiting fungal RNA and protein synthesis - fungicidal
Azole antifungalsdecrease ergosterol synthesis and inhibits cell membrane formation - fungistatic
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Section 3

Question Answer
Neuraminidase inhibitorsinhibits neuraminidase enzyme, preventing viral replication
Viral Replication BlockersInhibits replication by competitively binding to the enzymes that assemble viral DNA
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Section 4

Question Answer
Biguanidesdecrease hepatic glucose production and intestinal absorption, increase insulin sensitivity
SulfonlyureasStimulates insulin release from the beta cells
MeglitiinidesStimulates insulin release from the beta cells
Thiazolidinedionesincrease peripheral insulin sensitivity through PPARy agonsim
Alpha-glucosidase inhibitorsreversibly inhibits alpha glucosidase
SGLT2 inhibitorsInhibit in proximal renal tubules decreasing reabsorption of glucose and increasing urinary excretion
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