MB C13 Self Quiz

tokia's version from 2016-04-29 04:08


Self quiz chapter 13


Question Answer
1. Synthetic drugmade partly by microorganisms and partly synthetically in the lab
Antimicrobial agentchemical agent used to treat a disease caused by microbes
Chemotherapyuse of any chemical agents in the treatment of disease
Semisynthetic drugmade partly by microorganisms and partly synthetically in the lab
Antibioticmicrobial-produced chemical that inhibits growth of or kills other microorganisms
Chemotherapeutic agentany chemical agent used in medical practice
2. How has chemotherapy developed since Ehrlich's timeDevelopment of chemotherapy since Ehrlich's time first started with the concurrent development of sulfa drugs by Gerhard Domagk...with prontosil inhibition of Gram-positive bacteria and antibiotics by Alexander Fleming with Penicillium mold in the 1930s.Ernst Chain and Howard Florey in the 1940s helped to isolate and mass produce penicillin.After World War II many new antibiotics were discovered and marketed.
3. Why do scientists study soil and water microorganism when searching for a new antibioticsMany novel fungi and bacteria live there.
4. What are the differences between bacteriostatic and bactericidal disinfectantsBacteriostatic disinfectants only prevent growth whereas bactericidal kill microbes


Question Answer
5. Sulfanilamideantimetabolite
Erythromcininhibition of protein synthesis
Penicillininhibition of cell wall synthesis
Rifamycininhibition of nucleic acid synthesis
Polymyxindisruption of cell membrane function
Purine analog Vidarabineantimetabolite
Streptomycininhibition of protein synthesis


Question Answer
6. An antibiotic that contains a B-lactam ring in its structure isPenicillin
7. Cephalosporins resemble which antibiotic in their mode of action and their structurePenicillin
8. Which of the following is not a property of an antimicrobial agentmust be effective against viral diseases
9. A narrow-spectrum agent attacks a _____ different microorganisms while a _____-_____ agent attacks many different microorganismsfew...broad-spectrum
10. Penicillin is specific for bacteria because itinhibits cell wall synthesis


Question Answer
11. Doctors prescribe synergistic drug combination to treat bacterial infections. The purpose of such treatment is toprevent microorganisms from acquiring drug resistance
12. An antibiotic that has a broad spectrum of activity but may cause aplastic anemia isChloramphenicol
13. Which of the following is not a way in which antifungal drugs are effectivethey can impair the mitotic spindle apparatus
14. All of the following can be side effects of antimicrobial agents exceptHost "superimmunity"
15. The target for quinolones isDNA replication


Question Answer
16. Antimetabolites that block folic acid synthesis areSulfonamides
17. An antimetabolite that is effective against the Mycobacterium that causes tuberculosis isIsoniazid
18. The drug of choice for treating systemic fungal infections isAmphotericin B
19. Which of the following is not a way to determine microbial sensitivity to an antimicrobial agentAntagonism
20. What is interferonSecreted proteins elicited from virus-infected cells that induce neighboring cells to produce antiviral proteins that prevent these cells from becoming infected


Question Answer
21. AcyclovirHerpesvirus infections of the genitals
GanciclovirCytomegalovirus eye infections
IdoxuridineHerpesvirus infection of the eyes
RibavirinHantavirus plus a wide variety of unrelated viruses


Question Answer
22. Chloroquine and primaquine are the agents most widely used to treatMalaria
23. Which of the following is a reason why helminthic and protozoan diseases are difficult to treatThey have many biochemical pathways in common with man.
24. How do antihelminthic agents workThey suppress carbohydrate metabolism or act as neurotoxins


Question Answer
25. Chromosomal resistanceResistance due to microbial DNA
Nongenetic resistanceMicrobes that are either sequestered from antibiotic or lose their cell walls rendering them non susceptible to antibiotic action
Synergismadditive effect of two antibiotics
Extrachromosomal resistanceResistance due to resistance (R) plasmids
Cross-resistanceResistance due to microbial DNA
ResistanceMicrobe formerly susceptible to antibiotic action that is no longer affected by it


Question Answer
26. Indicate in the boxes the activity inhibited by the antibiotics and list some antibiotics which exhibit the activityBox 1..Inhibition of cell wall synthesis;Antibiotics:penicillin,bacitracin,cephalosporin,vancomycin.Box 2..Disruption of cell membranes function;Antibiotics,polymyxin.Box 3..Inhibition of protein synthesis;Antibiotics,tetracycline,erythromycin,streptomycin,chloramphenicol.Box 4.. Inhibition of nucleic acid synthesis;Antibiotics :rifamycin(transcription),quinolones(DNA replication),metronidazole.Box 5..Action as antimetabolites;Antibiotics:sulfonilamide,trimethoprim.