Malignant Hyperthermia

donna17's version from 2017-06-02 18:02


Question Answer
Signs of Malignant HyperthermiaRapid rise in body temperature to 105 degrees or higher after anesthesia is given, trunk or total body rigidity after anesthesia, Tachycardia, Tachypnea, Acidosis, Dark brown urine (rhabdomyolysis) with elevated myoglobin, eventual kidney failure due to destruction of muscle tissue, increased levels of CPK, Potassium, uric acid, and phosphate
Malignant Hyperthermia caused by autosomal dominant trait
Malignant Hyperthermia is caused when the infected person receives succinylcholine and/or inhalation anesthetics
The best course of action for MHis prevention, as it can be fatal if not treated promptly
Acute treatment of MHstop procedure, hyperventilate with 100% O2 at flows of 10 L/min or more, Dantrolene 2.5 mg/kg rapid IV repeated until there is control of the signs, bicarbonate for metabolic acidosis 1-2 mEq/kg if ABGs not available, cool the patient with core temp >39C and lavage open body cavities, apply ice to the surface and infuse cold saline IV, dysrhythmias usually respond to treatment of acidosis and hyperkalemia, Use standard drug regimens EXCEPT CCB (in the presence of dantrolene, cardiac arrest), treat hyperkalemia with bicarbonate, glucose, insulin, and calcium, high volumes of IV therapy