shevyatiwari's version from 2015-04-24 11:42


Question Answer
BactericidalF, bacteriostatic
Bind reversibly to 30S subunit of bacterial ribosome inhibiting RNA dependent protein synthesisF, 50 S
Erythromycin has low rates of S aureus resistanceF, high rates
Resistance of erythromycin in P acnes is approx 10%F, 50%
Erythromycin has erratic oral BA, short half life, frequent GI S/E and is an inhibitor of CYP3A4 and 1A2T
Clarithromycin is an azalideT - same as azithromycin
Telithromycin is an azalideF - a ketolide. No longer available
Cethromycin is a ketolideT
Active against GP, enterococcus and MRSAF - against GP but not enterococcus or MRSA
Clarithromycin is equally as potent as erythromycin against GP'sF, 2-4 times more potent
Azithromycin is equally as potent as erythromycin against GP'sF, 2-4 times less potent
Azithromycin is the most effective macrolide against M lepraeF, clarithromycin is
Erythromycin should be taken on an empty stomachT
The BA of clarithromycin is influenced by foodF, good absorption regardless
The BA of azithromycin is influenced by foodT - decreased with food
Macrolides should all be adjusted for renal diseaseF - azithromycin doesn't require adjustment. Erythromycin and clarithromycin do
GI S/E occur in up to 20% and are the most common S/ET
Ototoxcity due to erythromycin is worse at high doses and with renal/liver impairmentT
Clarithromycin causes the highest rates of QT prolongationF, erythromycin does
Clarithromycin tastes bitterT
Cholestatic hepatitis is commonF, uncommon
Azithromycin can cause irreversible deafnessT
Excreted in breast milkT
Erythromycin is safe in the third trimester for genital mycoplasma infectinosT
Azithromycin is a potent inhibitor of CYP3A4F, doesn't significantly affect it
Erythromycin > clarithromycin in terms of CYP inhibition T

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