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Lipid-lowering agents

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shainagong's version from 2018-03-08 23:27

Section

Question Answer
StatinsHMG-CoA reductase inhibitor --> decreases synthesis of mevalonate
Bile acid resins (coles-)Prevents intestinal reabsorption of bile acids
EzetimibePrevents cholesterol absorption at small intestine brush border
Fibrates Upregulate LPL --> increased TG clearance; activates PPAR-alpha to induce HDL synthesis
Niacin (vitamin B3)Reduces hepatic VLDL synthesis
PCSK9 inhibitors (-cumab)Inactivates LDL receptor degradation, increasing LDL removed from bloodstream
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