llbgurl's version from 2015-09-30 19:21


Question Answer
80 of childhood leukemiaALL
bone marrow replaced by leukemic cellsALL
frequently appears age 2 & 15 yearsALL
most common malignancy in children under 15ALL
peak age of clinical presentation 4 years
males 1:3 more oftenALL
caucasian more than black children 1:2ALL
10-20 times more frequent in down syndrome childrenALL
prognosis is really goodALL
poorer prognosisacute nonlymphoblastic leukemia (AML)
peak age 10 yearsacute nonlymphoblastic leukemia (AML)
appears most frequently in school-age children, insidious onset with lengthy remissionchronic myeloid leukemia (CML)
unknown etiology: infection, radiation, chemical, familial, chromosomalleukemia
increased uric acid levelselevated d/t rapid turnover of malignant cells
main complaint: pain in bonesleukemia
pale, bleeding, fever, and painleukemia
thrombocytopenia 85% leading to petechiae, purpura and scleral bleedingleukemia
fever in 61%associated with infection leukemia
diagnosis leukemiabone marrow biopsy
hemoglobin DECREASED, platelets DECREASED, WBC increased OR decreasedleukemia
lumbar punctureto r/o CNS involvement
suspect leukemiaER immediately for bone marrow aspiration and medical management
chemo usually lasts around 2 yearsleukemia
bone marrow transplantleukemia considered after first relapse
considered in remission ifNO leukemic cells in bone marrow and blood counts are WNL
learning problemsfrom chemo, may need remediation
immunizationscan begin once blood counts have stablized with KILLED vaccines ONLY
siblings vaccineNO LIVE VACCINES when child under treatment
late s/e of chemo in early childhoodcognitive delay, learning problems, growth/developmental delay
secondary malignant neoplasmsincreased risk for
avascular necrosis of boneleukemia
pulmonary fibrosis, renal insufficiency, cardiomyopathy and arrythmiasleukemia

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