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Leukemia Lymphoma

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gsafsaf's version from 2015-08-03 06:00

Non-Hodgkins Lymphoma

Question Answer
Burkitt epiadolescents
Burkitt HistoStarry Sky
Burkitt Sporadic formpelvis+abdomen
Burkitt LymphoblastsCD20+
Diffuse Large B epiMC non-hodgkins
Diffuse Large B clinical sxAgressive
Diffuse Large B can dvlp fromCLL/SLL
Diffuse Large B LymphoblastsCD20+
Follicular histoCleaved nuclei
Follicular SxPainless waxing+waning
Follicular can dvlp intoDiffuse Large B
Follicular RxRituximab
Follicular LymphoblastsCD20+
Mantle Cell EpiOlder males
Mantle Cell LymphoblastsCD20+, CD5+
Marginal Zone AssctnsHashimotos, Sjogrens, H pylori
Marginal Zone @ mucosal sites"MALToma"
Marginal Zone LymphoblastsCD20+
Burkitt translocationt(8;14)
Follicular translocationt(14; 18)
Mantle Cell translocationt(11;14)
8c-myc
11Cyclin D1
14Heavy chain Ig
18BCL-2
Adult T-cell labsHypercalcemia
Adult T-cell AssctnsHTLV (Japan, West Africa, Caribbean)
Adult T cell SxCutaneous lesions, Lytic bone lesions
Mycosis fungiodes LymphoblastsCD4+
Mycosis fungiodes Histocerebriform nuclei
Mycosis fungiodes SxSkin plaques
Mycosis fungiodes can dvlp intoSezary Syndrome (Leukemia)
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Leukemias

Question Answer
ALL epi<15
ALL assctnsDowns (after 5yo)
ALL better prognosist(12;21)
ALL worse prognosis, adultst(9;22)
ALL cell labsTdT+, CD10+
ALL PresentationMediastinal mass (like SVC syndrome)
ALL RxMOST responsive to therapy
ALL may spread toCNS + testes
CLL epi>60yo, MC adult leukemia
CLL cell labsCD20+, CD5+
CLL histoSmudge cells
CLL SxAutoimmune hemolytic anemia
CLL can change intoDiffuse Large B Cell lymphoma
SLLsame as CLL, but in lymph nodes
Hairy Cell LabsTRAP+ B cells
Hairy Cell SignsMarrow fibrosis --> dry tap
AML epi~65yo
AML LabsMyeloperoxidase+ in M3
AML HistoAuer Rods
AML risk factorsAlkylating chemo, radiation, myeloproliferative disorders
AML RxATRA
AML SxCan precipitate DIC
CML epi45-85
CML translocationt(9;22)
CML labsLow LAP
CML histoBasophils
CML RxImatinib
CML may accelerate toALL or AML w blast crisis
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