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Lecture 35 pentose phosphate pathway

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arne1's version from 2015-09-24 23:37

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Question Answer
pentose phsophater pathway is active inliver, lactating mammary gland, adipose tissue (provides NADPH for fatty acid synthesis). also in adrenal cortex, testes, ovary (synthesis of steroid hromones), erythrocytes, WBCs
oxidative phase of pentose phosphate pathway generatesNADPH
NADPH is used for reductive synthesis of FAs, steroid hormones, detox of hydrogen peroxide, cytochrome P450 system, phagocytosis in WBC, synthesis of NO
G6PD deficiency leads tohemolysis (no GSH = detox of H2O2 , is formed). GSH also maintains SH groups of proteins
Only NADPH producing pathway in RBCspentose phtosphate pathway
memorize

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