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L23 - Immunology - Antibodies B and T cells part 1 and 2

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malra16's version from 2018-01-11 15:19

Section

Question Answer
The L (light) and H (heavy) chain have different regions. Name them.They have variable and constant regions.
Segmental flexibility comes from which chain?The H chain
The constant region of L chains exist in two forms - Which?Kappa (k) and lampda
Which Ig protects against parasites?IgG
Which Ig is mainly found in tears, saliva and mucus?IgA
Which Ig, has an unknown function as of yet?IgD
Which Ig is the most prevalent soluble antibody?IgE
Which Ig is the first soluble antibody to appear in serum after immunization?IgM
What is an epitope?An epitope is a site where antibodies can bind.
What stablizes the IgG structure?Disulfide bonds-
What is an hapten?This is a foreign molecule that elicits antibody formation.
In plasma cells, what does class switching mean?It means that plasma cells which synthesize IgM, switch to IgG with the same antigen specificity.
What does class switching allow?It allows the specificity to be kept, allowing cells to produce other effector functions towards the antigen.
What does it require for a T-Cell receptor to recognize a foreign molecule?The molecule must be bound by proteins encoded by the genes of the major histocompatibility complex.
Which structure does Class I MHC proteins have?They contain an immunoglobulin fold motif and a Beta-microglobulin chain. They also contain one transmembrane chain, and are encoded by six different genes that are highly polymorphic.
Which structure does Class II MHC proteins have?They contain an immunoglobulin fold motif and 2 transmembrane polypeptide chains. They are most often encoded by six different genes that are highly polymorphic.
Which structure does T-cell receptors have?They contain an immunoglobulin fold motif, and they contain domains homologous to the V and C domains of the immunoglobulins. At the same time, they have two transmembrane polypeptide chains and they're encodede by V, D and J gene segments.
The immune system has 2 parts - Which?The innate and adaptive system
The innate system recognises what?Common pathogens from bacteria and viruses
In the adaptive system, which cell generates antibodies and the complement components?B - Cell lymphocytes
Which kinds of T-cells exist?Cytotoxic and helper T Cells
Light and heavy chains of antibodies has hypervariable regions generated by what?V, D and J genes.
Which region of the antibody recognises the antigen?The hypervariable
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