Iron Absorption and Lab Values and Hemochromatosis

veranellasel's version from 2015-06-23 15:43

Section 1

Question Answer
Ferritinintracellular storage of Fe3+
TIBCability to bind to Fe in blood
serum ironamount of Fe in blood
% saturation amount of transferrin that is bound to Fe
transferrintransports iron in the blood to liver and bone marrow macrophages for stroage
Why do we need ferritin?binds to intracellular iron to prevent free radical formation via Fenton Reaction
Which stain stains for iron?Prussian blue

Section 2

Question Answer
how is Fe transported from enterocyte into blood?through ferroportin
Where is iron absorbed in gut?Iron fist bro (duodenum as Fe2+)
folate jejunum
B12 in terminal ileum
What state does Fe have to be in when bound to heme?Fe2+
who turns Fe to 2+ state when being absorbed by intestine?DMT1 (ion channel)
hepaestinprotein that binds to ferroportin to allow Fe2+ to leave enterocyte and enter blood
Why does acidic food help w/ iron absorptiongoes from Fe3+ to Fe2+
hepcidinFe door and affects ferroportin to allow Fe2+ to leave

Section 3

Question Answer
HFE protein defective in primary hemochromatosis
HFE binds to what?binds to transferrin receptor
mutation in HFECysteine to tyrosine C282Y
hepcidin controls iiron absorption into blood
hepcidin MOAbinds to ferroportin (channel for Fe) and causes internalization of iron channel for death
How does HFE fit into hepcidin?Hfe controls signal and transduction of hepcidin (regulator)
HFE binds to?TfR2 to turn on hepcidin expression in the Smad pathway

Section 4

Question Answer
hemosiderosisdeposition of hemosiderin (iron)
hemochromatosisiron deposition dx
cirrhosis, diabetes mellitus, skin pigmentationhemochromatosis
Hemochromatosis causesCHF, testicular atrophy and risk of hepatocellular carcionma
lab values for hemochromatosishigh ferritin, high iron, low TIBC and high transferrin saturation

Section 5

Question Answer