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IPDM I WK 6 UI Alpha Adrenergic Agonists for SUI

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alchemist04's version from 2016-05-15 01:45

Section

Question Answer
What are the drugs for SUI?(1) Alpha-Adrenergic Agonists (2) Estrogens (3) Antidepressants (4) Duloxetine (5) Imipramine
What are the etiologies of SUI? (1)Increased Urethral MOBILITY
What are the etiologies of SUI? (2)(2) Intrinsic sphincter DYSFUNCTION
What are the etiologies of SUI? )3)(3) abrupt increase in INTRA-ABDOMINAL PRESSURE exceeds URETHRAL SPHINCTER closing pressure
What is the symptoms of SUI?loss of small amounts of urine with physical exertion (exercise, lifting, sneezing, coughing)
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What are the medications that could induce SUI (1)(1) Alpha antagonist
What are the medications that could induced SUI (2)(2) ACE Inhibitors
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What are the risk factors of SUI? (1)(1) Pregnancy or childbirth
What are the risk factors of SUI? (2)(2) Menopause
What are the risk factors of SUI? (3)(3) Cognitive impairment
What are the risk factors of SUI? (4)(4) Obesity
What are the risk factors of SUI? (5)(5) Prostatectomy
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Examples of Alpha-adrenergic agonists(1) Pseudoephedrine (2) Phenylephrine
Brand of PsuedoephedrineSudafed (16 - 60 mg TID or Q8h)
Brand of PhenylephrineNeo-synephrine (10 mg QID or Q6h)
MOA of alpha-adrenergic agonist(1) alpha-receptor agonist (2) vasoconstriction of smooth muscle
Side effects of Alpha-adrenergic are(1) HTN, (2) Headache (3) Insomnia (3) restless
ContraindicationsAll heart problems like Coronary artery disease, Tachycardia, Myocardial infraction, HTN, and Narrow angle glaucoma, renal failure
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MOA of estrogenenhances (1) proliferation of urethral epithelium (2) local circulation and numbers and or (3) sensitivity if urogential alpha-adrenergic receptors
Estrogen indicationsSUI or Urge UI, for female only, beneficial in post-menopausal woman, grade A
Estradiol brand isVagifem (vaginal tablet)
Estrogen brand isPremarin (Vaginal cream)
Estradiol ring brand isEstring (Vaginal ring)
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Antidepressants indicated for SUI are(1) Duloxetine (2) Imipramine
Duloxetine Non-FDA indications for womenSUI (only in Europe)
Duloxetine Non-FDA indications for menSUI and UUI
Duloxetine brand isCymbalta
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Question Answer
Duloxetine MOA (1)Serotonin and Norepinephrine Reuptake Inhibitor
Duloxetine MOA (2)Increase internal and external urethral sphincter activity
Duloxetine MOA (3)Increase muscle tone in the storage phase
Duloxetine side effects(1) Anticholinergic effects (2) HTN (3) Nausea (improves w/ time) (4) Bruxism
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Imipramine brand isTofranil
MOA of Imipramine (1)(1) Tricyclic Antidepressant (TCA)
MOA of Imipramine (2)(2) Inhibits NE and 5-HT re-uptake
MOA of Imipramine (3)(3) Antagonizes H1 and H2 receptors
MOA of Imipramine (4)(4) Desensitizes Alpha adrenergic receptors
Imipramine side effects(1) anticholinergic effects (2) Orthostatic HTN (3) Sedation (4) QTc prolongation
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Question Answer
Indications of Antidepressants are limited to (1)(1) if >/ additional indication for agent
Indications of antidepressants are limited to (2)(2) Mixed UI
Indications of antidepressants are limited to (3)(3) Nocturnal incontinent associated with altered sleep
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