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IPDM I WK 6 UI Alpha-1 Adrenergic Receptor Antagonists for Overflow UI

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alchemist04's version from 2016-05-16 15:00

Section

Question Answer
Non pharm option for Overflow UICatheter or Prostatectomy
Pathophysiology of Overflow UI(1) Detrusor under activity, (2) Bladder obstruction (3) both
Symptoms of Overflow UI(1) strain to void (2) weak urinary stream (3) Lower abdominal fullness (4) Sense of incomplete bladder emptying (5) may have frequency and/or nocturia
Risk factors of Overflow UI(1) Neurological dysfunction (2) Anatomic urethral (obstruction, BPH and Prostate cancer (3) Hysterectomy
Medication that induce Overflow UI(1) alpha- agonist (2) Anticholinergics (3) Cold and cough (4) CCB's (5) Opioids (6) TCAs
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Question Answer
Terazosin brand and dosing?Hytrin, 1-5 mh QHs
Doxazosin brand, dosing?Cardura, I - 8 mg QD
Alfusozin brand, dosing?Uroxatral, 10 mg QD
Tamsulosin brand and dosing?Flomax, 0.4 - 0.8 mg QD
Silodosin brand and dosing?Rapaflo, 4-8 mg QD
Bethanechol brandUrecholine
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Question Answer
MOA of Urecholinecholinergic agents that stimulate the release of ACh at the nerve ending, thereby activating PNS
Side effects of Urecholineurgent desire to urinate, abdominal cramp, diarrhea, seizure, flushing
Off-label indicationOverflow UI
Contraindicated forBradycardia, hypotension, asthma, parkinsonism
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Question Answer
MOA of Alpha-1 adrenergic receptor antagonists (1)(1) blocks alpha 1 adrenergic receptors
MOA of Alpha-1 adrenergic receptor antagonists (2)(2) relaxes smooth muscle of prostate, urethra, bladder neck
MOA of Alpha-1 adrenergic receptor antagonists (3)(3) improves urine flow rate
MOA of Alpha-1 adrenergic receptor antagonists (4)(4) Reduces symptoms of BPH
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Question Answer
Side effects of Alpha-1 adrenergic receptor antagonists (1)Orthostatic hypotension
Side effects of Alpha-1 adrenergic receptor antagonists (2)Nausea
Side effects of Alpha-1 adrenergic receptor antagonists (3)Abnormal ejaculation
Side effects of Alpha-1 adrenergic receptor antagonists (4)Arrhythrmias
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