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Ion Channels 2

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imissyou419's version from 2016-10-16 01:40

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Question Answer
nAChR channel structurepentameric, heteromeric - 2 alpha (where 2 Ach ligands bind), 1 beta, 1 gamma, 1 delta subunits, 4 transmembrane domains in each subunit w/ TM2 lining pore
nAChR domain structureextracellular N and C terminals
nAChR selectivity(-) charged residues makes for a non-selective cation channel
VG K+ channel structuretetrameric, homomeric, 6 transmembrane domains in each subunit
VG K+ channel domain structurecytoplasmic N and C terminals, loop domain H5 (where TEA binds) forms selectivity filter, S4 sensor (full of + charged arginine)
VG Ca+ and Na+ channels structuretetrameric (1 subunit with 4 domains), 6 transmembrane domains in each domain
VG Ca+ and Na+ domain structurecytoplasmic N and C terminals, loop domain H5 forms selectivity filter, S4 sensor, VG-inactivation between III and IV domain
Gap junctions channel structure12 subunit protein (2 hemichannels coming together - 6 connexins form a hemichannel)
Connexin structure4 transmembrane domains, cytoplasmic N- and C- terminals
Gap junction propertieselectrical synapse, short synaptic delay, synchronous activation, large enough for small molecules, increased intracellular acidity or Ca+ closes gap junctions
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