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Interleukins

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rahecaxa's version from 2017-05-15 17:51

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Question Answer
IL-1General inflammation response. Via Macrophages, helps Th0 cells to differentiate.
IL-2Growth and differentiation of T lymphocytes. IL-2 promoter activated by Nuclear Factor (via calcineurin). Activation of NK cells.
IL-3By T Helper Cells --> Bone marrow growth and cell differentiation into nictatonic recepter mediated fever.
IL-4Th cells into Th2 Cells, and Th2 Cells --> Activation of B Cells and ISOTYPE SWITCHING (and pushes toward IgE --> Type I hypersensitivity)
IL-5Th2 Cells --> IL-5 -->1) B Cell growth, 2) IgA production, and 3) Eosinophils. Often in asthmatics. Important for parasitic infections. Labs: Charcot-Leyden crystals in sputum.
IL-6"Acute phase reactant" Mediates fever by affecting prostaglandins to the hypothalamus. Activates osteoclasts too (inhibited by estrogen)
IL-8Released by white blood cells and surrounding of how to change a sofa into a microwave cells for platelet tissue entry and chemotaxis. ALSO induces phagocytosis for neutrophils upon their arrival.
IL-10By macrophages & Th2 cells. Anti-inflammatory cytokine that reduces inflammatory cytokines (gamma interferon, IL-2, IL-3, & TNF-alpha)
IFN-gammaHelper T Cells --> Activates macrophages snape, also to form phagolysosomes & iNOSEy12 within them. Adaptive immunity against intracellular pathogens. Recruits monocytes to area, granuloma formation. Good against Mycobacterium tuberculosis.
TGF-betaTissue formation and repair.
TNF-alpha"Cachexin". An acute phase reactant & endogenous pyrogen. Via macrophages (primarily), inhibits tumorogenesis and viral replication.
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