Injury markers

arne1's version from 2015-09-20 02:05


Question Answer
MI troponinsTroponin C does not have an isoform that is specific for the heart, but the cardiac isoforms cTnI and cTnT are measured as MI injury marker.
LDH subunits in heart musclemainly LDH-1 (H4) and LDH-2 ( H3M) with a high LDH- 1 to LDH-2 ratio.
LDH in RBCsRBCs contain also mainly LDH-1 and LDH-2, but with a low LDH-1 to LDH-2 ratio.
LDH in skeletal muscle and livermainly LDH-5 (M4)
liver injury markersAlanine aminotransferase (ALT) - more specific - and aspartate aminotransferase (AST) ratio of AST/ALT ratio above 2 can indicate, that the liver mitochondria are damaged (due to EtOH)
enzyme indicative of large EtOH intakeGGT - gamma-glutamyl-transpeptidase
Pts with liver cirrhosis or bile duct obstruction show increasedAlkaline phosphatase (ALP) - also increased in bone cancer but different isozyme (sALP - naturally elevanted in kids and pregnant women). concommitant increased GGT and bilirubin points to liver/bile and not bone
serum injury marker enzymes for pancreatitisalpha-amylase and (pancreatic) lipase
prostate cancer markerPSA
liver cancer markeralpha-fetoprotein (AFP).