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Inflammation and CVD Studies

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bethdrysdale94's version from 2017-01-21 14:10

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Question Answer
Bermudez et al (2002) IL6 and risk factors study information340 postmenopausal women, no CVD. RISK FACTORS: >60yo, surrent smoker, sedentary lifestyle, BMI >27, SBP >140, diabetes.
Bermudez et al (2002) study findingsmore risk factors present = more IL6 and CRP. less risk factors = less IL6. CRP shows less of a trend with exercise in women than with men
Bermudez et al (2002) study strenghths and limitationsVery broad categories with exercise (never, once/week, more than once per week). Self report bias. Cross sectional study
Church et al (2002) CRP and exercise study info722 men >50yo. Exercise quintiles depending on VO2 max. measured CRP blood levels
Church et al (2002) study findingsnegative correlation between CRP and exercise quintile
Church et al (2002) study strengths and limitationsNOT self report. adjusted for confounding factors eg smoking, BMI, age, other inflammatory disease. STRONG study, with strong relationship BUT was cross-sectional
Hamer et al (2012) CRP, IL6 and exercise study info4289 men and women, 10 yr follow up. exercise questionnaire asking about frequency and length.
Hamer et al (2012) study findingsaround 50% stuck to activity guidelines/week (30 mins 5 days/week). in both groups, IL6 and CRP increased over 10 years. exercise group = lower CRP and IL6 in comparison throughout 10 years. exercise group retained a level of protection from IL6 increase from year 1-10 ie exercise prevented increase to non-exercise level. Those who reported an increase in exercise over 10 years occasionally had lower levels of CRP and IL6 at follow up
Hamer et al (2012) study strengths and limitationsself report BUT validated questionnaire, adjusted for confounding variables INCLUDING employment grade.
Viana et al (2014) walking and CKD status study info6 month walking intervention for advanced CKD patients. measured plasma IL6 and IL10
Viana et al (2014) study findingsexercise group: decreased IL6, increase IL10, decreased IL6/IL10 ratio. control group: no change in IL6 or IL10 or ratio.
Viana et al (2014) strengths and limitationsgroup not representative of population, niche study, but was longitudinal, exercise intervention controlled and monitored
Smith et al (1999) cardiac rehab programme study info6 month supervised training effect on cytokine production, in patients post major cardiac event.
Smith et al (1999) study findingsdecrease in: IFN, TNF. increase in: IL4 and TGF-beta - exercise can reduce inflammation even in high risk patients
Smith et al (1999) study weaknessesniche group, unaware of importance of his study
Pedersen et al (2001) IL6 influences study infomuscle derived IL6 looking at influences on blood supply of carbs and fats
Pedersen et al (2001) study findingsIL6 is only released at a certain intensity of exercise but increases: lipolysis, glycogenolysis (at local muscles)
Pedersen et al (2001) study strengths and limitationsreview, secondary research if anything. takes into account lots of different studies and has good indicator or what strenuous exercise is
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