Immunology

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Immunology (by jingalingaling)
Immunology (by cbutler)

Cell surface proteins

Cell	Surface markers
Helper T cells	CD4, TCR, CD3, CD28, CD40L (for B cell switching)
Cytotoxic T cells	CD8, TCR, CD3
B cells	IgM, CD19, CD20, CD21 (receptor for EBV), CD40 (for B cell switching), MHCII, B7 (for binding CD28 on Thelper cells)
Macrophages	MHCII, B7, CD40, CD14 (endotoxin receptor for LPS), receptors for Fc and C3b
NK cells	receptors for MHC I, CD16 (binds Fc of IgG), CD56
All cells except RBCs	MHC I
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Alternative for quizzing yourself

Surface marker	Cell types
CD3	helper T and cytotoxic T (muromonab is anti-CD3)
CD4	helper T
CD8	cytotoxic T
TCR	helper T and cytotoxic T
CD28	helper T
CD40L	helper T
CD40	B cell, macrophages
IgM	B cell
CD19	B cell
CD20	B cell (rituximab is anti-CD20)
CD21	B cell (EBV)
B7	B cell, macrophages
MHC II	B cell, macrophages, dendritic cells (all APCs)
CD14	macrophages
Receptors for Fc and C3b	macrophages
Receptors for MHC I	NK cells
CD16	NK cells (binds Fc of IgG)
CD56	NK cells
MHC I	all nucleated cells
CD 10	CALLA (ALL)
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Hypersensitivity disorders

Disorder	Reaction
anaphylaxis (bee sting, some food/drug allergies)	I
allergic and atopic d/o (rhinitis, hay fever, eczema, hives, asthma)	I
hyperacute rejection	II
hemolytic anemia	II
pernicious anemia	II
ITP	II
erythroblastosis fetalis	II
acute hemolytic transfusion reactions	II
rheumatic fever	II
Goodpasture's syndrome	II
bullous pemphigoid	II
pemphigus vulgaris	II
Graves' disease	II
myasthenia gravis	II
IgE-mediated killing of invasive parasite/eggs (e.g., helminth) [IgE binding --> eosinophils have Fc R that bind IgE --> eosinophils release MBP --> destroys egg]	II
SLE	III
RA	III
PAN	III
PSGN	III
serum sickness	III
arthrus reaction (e.g., swelling and inflammation following tetanus vaccine)	III
hypersensitivity pneumonitis (e.g., farmer's lung)	First exposure - Ig Second exposure - III Chronic exposure - IV (granulomatous inflammation)
T1DM	IV
MS	IV
GBS	IV
Hashimoto's thyroiditis	IV
GVHD	IV
PPD (M. tb test)	IV
contact dermatitis (e.g., poison ivy, nickel allergy)	IV
acute transplant rejection	IV
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