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Immunology Buzz Words 2

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drewmazurkiewicz's version from 2017-01-11 05:35

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Question Answer
T cells associated with what area of spleenPALS - periarteriolar lymphatic sheath
what stage of immune response has increase in serum specific ab levelslog phase (replicating Ab)
what cytokines do APCs secrete to activate T-helper cellsIL-1, IL-6, TNF-alpha
what Ig does Ab-dependent cell-mediated cytotoxicity of parasitesIgE
Which Ig has high affinity for Fc receptor on mast cells and basophilsIgE
what Ab does the allergic responseIgE
What Ig does activation of complement, opsinization, and Ab-mediated cytotoxicityIgG
Which Ig activates alternate pathwaysIgA
which Ig neugralizes bacterial endotoxins, viruses, and prevents adherenceIgA
what is defined by antigen-binding specificityidiotypes
what are genetic variants of a molecule within members of same speciesallotypes
what are dif classes/subclasses of the same gene productIsotypes
what are 4 phases of immune defense systemrecognition, amplification, regulation, elimination (RARE)
molecule that triggers an immune response (what's it called)immunogen (must be foreign and have at least two antigenic determinants)
what MHC class doesn't particiipate in immune cell communication by direct contactMHC class III
95% of all TCRs consist of which typesalpha and beta chains
TCRs found on skin and mucosal surfaces are which typesgamma and delta TCRs
strength of association between multiple antibody-binding sites and multiple antigenic determinantsavidity (more than one binding site)
IgA form in secretionsdimer (monomer in blood)
what's the portion of a large antigen that is recognized and bound to Ab, contains 5-6 AAs or 4-5 hexose unitsantigenic determinant (aka epitope) -- epitopes bind to idiotypes
what results from cleaving an Ab with papaintwo Fab and Fc regions. still able to participate in precipitation and agglutination because still has a Fab region
type of binding to an idiotype of IgG or a Fabaffinity
cytokines secreted by helper T cells to activate APCIFN-gamma, IL-4
what is target for elimination of abnormal host cellsMHC I
what stage of immune response has stable levels of Ab in serumplateau
what stage of immune response has catabolism without synth of antibody, causing level declineantigen processing
what stage in immune response is involved from first antigen presentation to first detectable levelLag phase
what presents exogenous peptides to helper T cellsMHC II
which 4 T helper cell cytokines are involved in differentiationIL-4, IL-5 (both secreted by TH2 cells, promote differentiation of B cells and class switching), IL-6 (secreted by Th stimulates accute phase reactants), IL-10 (inhibitory of TH1, cell mediated immunity and activates TH2)
co-stimulatory molecules necessary for B cell differentiaton (class switching)CD-40 and CD-40L
which cytokine is chemotactic for neutrophilsIL-8 (other chemotactants: C5a, IL-8, LTB4, Kallikrien)
two functions of thymus in T cell differentiatnhormone secretion for T cell differentiation, t cell education to recongize self
three rules of clonal selectionone cell type, one Ab type, random selection of hypervariable regions and only cells w/bound antigen undergo clonal expansion
last maternal IgG leaves circulation when9-15 months
which cytokine important in lymphoid development is produced by bone marrowIL-7 (7 upside down looks like L for lymphoid)
which region of thymus contains mature T cellsmedulla (immature in cortex - darker than medulla)
cell surface markers of T helper cellsCD-28 and CD-8
cell surface markers of cytotoxic T cellsCD-28 and CD9
complement fragments that cause lysis of cellsC5b-9
complement fragment deficient in pt with repeated infections, fever, rash, arthralgia (esp pyogenic URIs/sinus)C3
complement deficiency that leads to increased susceptibility to type III hypersensitivityC3
deficiency in Decay Accelerating Factor (GPI-anchor enzyme)complement-mediated hemolysis = paroxysmal nocturnal hemoglobinuria
3 factors in charge of opsonizationIgG, C3b, mannose binding protein
which cell surface marker binds to C3d fragmentsCD21
which disease associated with inherited deficiency in NADPH oxidase and what infections do they getchronic granulomatous disease, susceptable to catalase positive organisms like staph
which cells are antigen specific and have MHC restricted killingCytotoxic T cells
which large granular lymphocytes have CD 16 and are not antigen specificNK cells - also have CD56 and don't secrete immunoglobulins
which lymphocytes have CD56 and do not secrete immunoglobulinsNK cells - also have CD16 and are not antigen specific
what three complement fragments are also anaphylatoxinsC3a, C4a, C5a
pathology associated with low levels of Ig that persist in kids for up to two yearstransient hypogammaglobulinemia of childhood - can be normal from 3-12 months (physiologic hypogammaglobulinemia of infancy)
cell surface marker found on pre-T cellsTdt
cell surface marker required for class-switchingCD40
large granular lymphocytes stimulated by IL-2 and IFN-gamma and are activated by natural killer cellslymphockine-activated killer (LAK) cells
which cells regonize the Fc region of IgG and carry out antibody dependent cell-mediated cytotoxicitykiller cells
4 chemotactic agens for neutrophilsC5a, IL-8, LTB4, bacterial peptides (or kallikrein)
5 main oxidizing reactions used to kill ingested organismsH2O2, Superoxide, Hydroxyl radical, myeloperoxidase, hypochlorous acid
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