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Hypoglycemics

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cmeshbe's version from 2015-07-12 18:58

Section

Question Answer
sulfonylureasglipizide - clsoes K channels to depolarize B cells, increases insulin secretion, failure rate overtime due to decreased B cell funtion,risk of hypoglycemia, sulfa allergy
GLP-1 analogsexenatide - increases insulin secretion and delays gastric emptying, injectable, associated with weight loss, N/V, pancreatitis, rare hypoglycemia
glitazonesPioglitazone 2nd line for initial therapy after metformin, PPAR-gamma nuclear transcription analog, increases insulin sensativity, associated with weight gain, CHF exacerbation, increased fractures and hepatotoxicity monitor LFTs
AcarboseAlpha glucosidase inhibitor - decreased glucose absorption, GI disturbance
SitagliptinDDP-4 inhibitor blocks inactivation of incretins e.g. GLP-1 associated with pancreatitis
PramlintideAmylin analog - decreases glucose absorption and GI motility - injectable, associated with weight loss,
repaglinidelike sulfonylureas increases B cell insulin secreation
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