Create
Learn
Share

HIV Drugs

rename
amyhan's version from 2016-05-20 17:22

Drug Classes

Question Answer
Abacavir (ABC)NRTI
Didanosine (ddl)NRTI
Emtricitabine (FTC)NRTI
Lamivudine (3TC)NRTI
Stavudine (d4T)NRTI
Tenofovir (TDF)NRTI (nucleoTide)
Zidovudine (ZDV, formerly AZT)NRTI
-navirProtease inhibitors
DelavirdineNNRTI
EfavirenzNNRTI
NevirapineNNRTI
EtravirineNNRTI
RilpivirineNNRTI
RaltegravirIntegrase inhibitor
ElvitegravirIntegrase inhibitor
DolutegravirIntegrase inhibitor
EnfuvirtideFusion inhibitor (binds gp41, inhibiting viral entry)
MaravirocFusion inhibitor (binds CCR-5 on surface of T cells/monocytes, inhibiting interaction with gp120; can only be used in pts infected with all R5 virus)
memorize

Toxicities

Question Answer
Bone marrow suppression (megaloblastic anemia)Zidovudine
Pancreatitis & peripheral neuropathyDidanosine, Zalcitabine, Stavudine
Hepatic steatosisDidanosine, Stavudine
Hypersensitivity reactionAbacavir
Lactic acidosisNucleoside NRTIs
RashNNRTIs
HepatotoxicityNNRTIs
Neuropsychiatric symptoms (nightmares, vivid dreams, dizziness, worsening depression)Efavirenz
False-positive drug test to cannabinoidsEfavirenz
Teratogenic/contraindicated in pregnancyEfavirenz, Delavirdine
Cannot be taken with meds that decrease gastric acid, must be taken with foodRilpivirine
GI intolerance (nausea, diarrhea)Protease inhibitors (most common AE)
Inhibit cytochrome P450Protease inhibitors (esp. Ritonavir)
Hyperlipidemia/hypertriglyceridemiaProtease inhibitors
LipodystrophyProtease inhibitors
PancreatitisRitonavir
NephrolithiasisIndinavir, atazanavir
Increased bilirubinAtazanavir
Contraindicated with protease inhibitors because can decreased PI concentrationRifampin
Increased creatine kinaseIntegrase inhibitors
Skin reaction at injection sitesFusion inhibitors
Increased risk bacterial pneumoniaFusion inhibitors
memorize