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Hepatitis Drugs

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tsdownstate2018's version from 2015-04-23 22:10

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Question Answer
For what two hepatitis viruses is there a vaccine?HAV (RNA) and HBV (DNA)
For what three hepatitis viruses is there no prophylaxis?HCV, HDV, and HEV
What does SVR stand for?Sustained Viral Remission, absence of viral particle at least 12 weeks after treatment.
Lamivudine, what kind of drug? What does it treat?Nucleoside Reverse Transcriptase Inhibitor, treats Chronic HBV, mild headache, insomnia, GI discomfort
Adefovir what kind of drug? What does it treat?NRTI, more effective than lamivudine, treats chronic HBV, mild headache, insomnia, GI discomfort
Entecavir what kind of drug? What does it treat?NRTI, more effective than Adefovir, trans chronic HBV, mild headache, insomnia, GI discomfort
Tenofovir treats chronic HBV, what are its side effects?Renal Impairment, Renal Failure, decreased bone density
What does pegylation do for IFNIncreases half life.
What hepatitis viruses does IFN treat?HBV and HCV
Ribavirin is used to treatHCV, but must be combined with other drugs.
What are the side effects of RibavirinDoes dependent hemolytic anemia, fatigue, rash, insomnia, depression.
What two proteins are targeted by Harvoni, what genotype?NS3 and NS5B, genotype 1
What is NS3? What is its targeted drug?Protease, simeprevir
What is NS5B? What is its targeted drug?RNA polymeras, Sofosbuvir
What is the genome of HCV, transmissionssRNA, blood
What is the genome of HBV, transmissiondsDNA, circular but not continuous, blood
What is the genome of HAV transmissionssRNA, fecal oral
What is the genome of HDV, transmissiondefective ssRNA, blood
What is the genome of HEV, transmissionssRNA, Fecal Oral
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