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Hepatitis and Liver diseases

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sgthuan's version from 2017-07-11 17:42

HCV - Direct Acting Antiviral -- BBW for reactivating HBV, CI with strong CYP3A4 inducers, increased risk of myopathy with statins

genericbrandclassdrug pearl
sofosbuvirSovaldiNS5B polymerase inhibitor400mg qd, serious Bradycardia with sofosbuvir + another DAA + amiodarone - AVOID, NEVER monotherapy
sofosbuvir + ledipasvirHarvoniNS5B polymerase inhibitor + NS5A replication complex inhibitorqd, ***AVOID acid suppressant therapy - PPI or H2RA, ** Avoid with amiodarone
sofosbuvir + velpatasvirEpclusaNS5B polymerase inhibitor + NS5A replication complex inhibitorqd, approved for all genotypes, ***AVOID acid suppressant therapy - PPI or H2RA
simeprevirOlysioNS3/4A Protease inhibitor150mg qd, screening for NS3 Q80K polymorphism, bradycardia with amiodarone, NEVER monotherapy
daclatasvirDaklinzaNS5A replication complex inhibitor+ sofosbuvir, CI - strong 3A4 inducers
paritaprevir + ritonavir + ombitasvirTechniviePI/booster/NS5A***2 tab qAM with MEAL, CI - child pugh B or C & strong 3A4 inducers, hepatic decompensation & failure with cirrhosis, especially with "ethinyl estradiol"
paritaprevir + ritonavir + ombitasvir + dasabuvirViekira Pak, Viekira XRPI/booster/NS5A/NS5BPak - 2 tab qAM + dasabuvir BID with MEAL, XR - 3 tab qAM with MEAL, CI - child pugh B or C & strong 3A4 inducers, hepatic decompensation & failure with cirrhosis, especially with "ethinyl estradiol"
elbasvir + grazoprevirZepatierNS5A/PI1 tab qd, ***CI - child pugh B or C & strong 3A4 inducers
ribavirinRibasphere, Moderiba, CopegusHCVNEVER monotherapy, BBW - serious teratogenic - wait 6 months for pregnancy, *** Hemolytic Anemia; can increase hepatotoxicity effects of all NRTIs
pegylated interferon alphaPegasys (HBV&HCV), PegIntron, Sylatron (HCV)interferonSQ qweek, neuropsychiatric, autoimmune, ischemic or infection,
tenofovir TDFVireadNRTIs for HBV300mg qd, ***Renal toxicity, Fanconi, osteomalacia, lactic acidosis, 1st line for HBV
tenofovir TAFVemlidyNRTIs for HBV25mg qd, ***Less Renal toxicity, Fanconi, osteomalacia, lactic acidosis, 1st line for HBV
entecavirBaracludeNRTIs for HBV0.5-1mg qd, check HIV infection, *** Take on EMPTY STOMACH
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