Hepatitis and liver disease

vitohuxo's version from 2016-07-04 18:42


Question Answer
interferon alfa medicationstx of hep A and hep B. pegylated forms have polethylene glycol added which prolongs half life. cause many adverse effects. flu like symptoms pretreat with apap and antihistamine
nucleoside/tide reverse transcriptase inhibitors (NRTIs)used for hep B. inhibit HBV replication. all patients should be tested for HIV. if they do need therapy approp for both
nucleoside/tide reverse transcriptase inibitors decrease dosing crclunder 50
nucleoside/tide reverse transcriptase inhibitors (NRTIs) boxed warninglactic acidosis and severe hepatomegaly with steatosis, can be fatal
viread tenofovir. nucleoside/tide reverse transcriptase inhibitors (NRTIs). renal toxicity side effect
do not use this NRTI for HIV treatmentepivir HBV, can result in HIV resistance
ribavirin HCV indication with other agents, never as monotherapy. hemolytic anemia, teratogenic if male or female taking...avoid pregnancy 6 months after use
protease inhibitorsindicated for chronic HCV infection- must be used in combo.
olysiosimeprevir- protease inhibitor HCV. must be used in combo other drug,
recommended screen for NS3 Q80k polymorphism, if positive then other therapy considersimeprevir
sovaldisofosbuvir- chronic HCV, monotherapy not recc.
harvonisofosbuvir + ledipasvir- chronic HCV - acid suppresive therapy should be avoided or minimized
daklinzadaclatasvir- chronic HCV- monotherapy not recc. used with sofosbuvir
technivieparitaprevir/ritonivir/ombitasvir- chronic HCV- sig DI potential ethinyl estradiol- must stop before sue
viekira pak paritaprevir/ritonavir/ombitasvir + dasabuvir - chronic HCV- ethinyl estradiol products must stop before use
regimens duration tx HCV is12 weeks without cirhosis and 16 or 24 weeks with cirhossis
used to prevent and treat wernicke korsakoffe syndromethiamine - vitamin b1
beta blockers used for secondary prevention variceal bleedingnadolol (coragrd) and propranolol (inderal)
first line therapy for hepatic encephalopahty teatment and preventionlactulose
ascites treatmentspironolactone by itself or with lasix...lasix by itself not effective