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Hemolytic

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happybee's version from 2017-04-22 17:29

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Question Answer
intravas --> serum haptoglobin?low
intravas --> haemoglobinuriahigh
intravas--> hemosiderinuriahigh
hemolytic (both extra and intra) --> what 3 things increaseLDH, reticulocyte, unconjugated bilirubin increase
warm acquired autoimmune --> which IgIgG
what happen in warm? (--> extra)phagocytosis --> loss of membrane --> spleen to be destroyed
associations with warm (3)CLL, SLE, RA
all b cell problems can be treated with what?including this warm anti- CD20 - rituximab
cold acquired autoimmune - which IgIgM
cold DAT +ve and what +ve (think about path)C3
is cold intravas or extravasintravas
clinical features of cold acrocynosis
associations with cold (2)mycoplasma, EBV
MAHA associated with (plt)thrombocytopenia
2 examples of MAHATTP, DIC
TTP pentagon renal, cns patho, fever, thrombocytopenia, anaemia
causes of TTPpreg, SLE
rx of TTP palsma exchange
PT and clotting blood test in TTPnormal
plt in TTPlow
DIC causes sepsis, trauma, obstetric, pancreatitis, malignancy, nephrotic, transfusion
DIC inv APTT and PTincrease
DIC fibrinogendecrease
DIC d- dimer raised
DIC rxFFP
rx of warm steroid
MAHA (TTP, DIC) DAT ?-ve
warm haemoglobinuria ?no
memorize

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