Heme Onc - 4 of 4

arold001's version from 2015-12-22 06:43

Section 1

Question Answer
Drugs that inhibit microtubule FORMATIONvinca alkaloids
Drug that inhibits microtubule disassemblyPaclitaxel
folic acid analog that inhibits DHF reductase --> decreases dTMP --> decreases DNA and protein synthesismethotrexate
whats the rescue drug for methotrexate overdose?Leucovorin = folic acid
pyrimidine analog thats activated to 5F-dUMP which inhibits thymidylate synthase --> decrease dTMP --> decrease DNA5-Fluorouracil
whats the MOA of Cytarabine?pyrimidine analog that inhibits DNA polymerase
whats the MOA of Azathioprine and 6-MP?Purine analog that decreases purine synthesis (activated first by HGPRT)

Section 2

Question Answer
name 4 antitumor antibiotics, which generates free radicalsDactinomycin, Doxorubicin, Danorubicin, Bleomycin
whats the MOA of Dactinomycin?intercalates DNA (tx childhood tumors)
Whats the MOA Doxorubicin?generates free radicals. Intercalates in DNA --> breaks DNA --> decreases replication
class of drugs that attaches to alkyl group on guanine --> crosslinks DNA --> cant replicateAlkylating agents
whats the MOA of cyclophosphamide?alkylating agent = attaches guanine N7, induces crosslinking
whats the MOA of Ifosfamide?alkylating agent
alkylating agents that can tx brain tumors since they cross the BBBNitrosamines = carmustine (-mustine)
Whats the MOA of Busulfan?alkylating agent
what 4 drugs are associated with nephrotoxicity and otoxocity?Vancomycin
Loop Diuretics

Section 3

Question Answer
alkaloid that binds to tubulin in M phase and blocks polymerization of microtubules so taht mitotic spindles cant form vincristine, vinblastine
Whats a side effect of vinblastine?vinblastine BLASTS bone marrow
what drug hyperstabilizes microtubules in M phase so mitotic spindle can break down?Paclitaxel = "taxes are what stablize society"
whats the MOA of cisplatin?cross-linkes DNA --> treats testicular cancer
what drug prevents cisplatin-induced nephrotoxicity?Amifostine = free radical scavenger
whats the MOA of Hydroxyurea?inhibits ribonucleotide reductase --> decrease DNA synthesis (S-phase spefic)
what 3 drugs are used to treat testicular cancer? ("Eradicate Ball Cancer"Etoposide, Bleomycin, Cisplatin
whats the toxicity of Trastuzumab?cardiotoxicity "men in STUZ will break your heart"
Whats the MOA of VemurafenibB-Raf kinase inhibitor with V600E mutation
What does Vemurafenib tx?melanoma
Whats the of MOA Bevacizumab?mab against VEGF = inhibits angiogenesis
whats the toxicity of 5-FU, 6-MP, methotrexate?myelosuppression

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