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Hematology

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fussion's version from 2017-05-22 03:25

RBC inclusions

Question Answer
acanthocyteschange in lipid content of cell membrane
acanthocytesliver diseaseabetalipoproteinemiaMcLeod phenotype
basophilic stipplingribosome RNAhemolytic anemia
basophilic stipplingMegaloblastic anemiathalassemia
basophilic stipplingPbAralcoholism
teardrop cells/dacrocytesbenign conditions (thalassemia, Megaloblastic anemia)myelophthisis
echinocytes (burr cells)uremia/burnPK deficiencypostsplenectomyartifact
elliptocytesFe defB12 deffolate def
elliptocytesmyelodysplasiahereditary elliptoctyosis
Heinz bodies"golf balls" supravital staindenatured HbG6PD def or unstable Hb
Bite cells (stain)supravital stain
Bite cellsdenatured HbG6PD def or unstable Hb
blister cells (stain)supravital stain
blister cellsdenatured HbG6PD def or unstable Hb
Howell-Jolly bodiesresidual nuclear (DNA) fragmentaspleniamyelodysplasia
macrocytosisneonate to 2 mos
oval macrocytesMegaloblastic (folate or B12 def)
round macrocyteschronic liver failure, hypothyroidism, myelodysplasia
microcystosis2 mos to childhood
pappenheimer bodiesFe containing mitochondria
pappenheimer bodiesaspleniasideroblastic anemia
schistocytesmicroangiopathic hemolytic anemias
schistocytes(DIC, TTP, HUS, HELLP)
spherocytesankryin
spherocytesautoimmune hemolytic anemia (extravascular hemolysis)hereditary spherocytosis
stomatocytesspecific band 3 protein defect
stomatocytesalcoholDilantinRh null phenotypehereditary stomatocytosis
target cellsthalassemiaHb Cliver disease
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calculations

Question Answer
manual hematocritpacked red cell column height/total height
MCVHct/RBC
MCHCHb/Hct or Hb/(RBC counted x MCV measured)
MCHHb/RBC
corrected WBC for nRBC[uncorrected WBC/nRBC + 100] x 100
reticulocyte indexreticulocyte count X Hct/norm Hct (45)
retic production indexretic index x correction factor
retic correction factorHct >35 = 1.0, 26-35 = 1.5, 16-25 = 2.0, <16 = 2.5
How many platelets if 1 plt seen at 100x20,000
1SD of MCVMCV(RDW-CV)
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drugs

Question Answer Column 3
Abciximab(GPIIb/IIIa inhibitor)half life 15-30min. need 48 hours to return to 50% baseline. Rapid reversal with platelet transfusion
Other GPIIb inhibitorseptifibatide, tirofiban
P2Y12 receptor inhibitorsclopidogrel, ticlopidine
Direct Xa inhibitorsapixaban, rivaroxaban
Direct thrombin inhibitorsargatroban (alternative in HIT pts), dabigatran (rapid reversal prothrombin complex concentrate or discontinue drug because short half like), hirudin
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