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Hematology-pharm

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drnieves's version from 2017-06-21 13:21

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Question Answer
Direct Xa inhibitorsApixaban, Rivaroxaban
Apixaban, RivaroxabanBind to and directly inhibits Xa
Direct Xa inhibitorsTx and prophylaxis of DVT Stroke prophylaxis in pts with afib.
Direct Xa inhibitor ADRBleeding
RivaroxabanPE prophylaxis
EnoxaparinLMWH. For use in pregnant women.
LMWHEnoxaparin, dalteparin, fondaparinux.
Enoxaparin, dalteparin, fondaparinux.LMWH
TamoxifenSERM. Antagonist in breast. Block ER+ cells.
Breast cancer tx and preventiontamoxifen
Agonist in bone. Tx osteoporosisRaloxifen
Tamoxifen risksendometrial cancer.
Antagonist in endometriumRaloxifen
Trastuzumab MOAMonoclonal ab against HER-2 (c-erbB2) (tyrosine kinase R). Kills cancer cells with HER2 overexpression.
Intracellular signaling and ADCCTrastuzumab
Trastuzumab useHER 2 breast cancer and gastric cancer.
Trastuzumab toxicityCardiotoxicity.
Methotrexate toxicityFolinic acid (leucovirin)
Reduced form of folic acid that doesn't need dihydrofolate reductaseFolinic acid
MethotrexateFolic acid analog. Inhibits dihydrofolate reductase= decrease dTMP and DNA.
Methotrexate useleukemias, lymphomas, choriocarcinomas, sarcomas, ectopic pregnancy, abortion, RA, psoriasis, IBD, vasculitis.
Methotrexate ADRmyelosuppression, hepatotoxicity, mucositis, pulmonary fibrosis.
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