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Griseofulvin

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shevyatiwari's version from 2015-04-25 03:02

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Question Answer
Isolated from a bacteriaF, from a mould
Metabolised in the liver to 6-demethyl-griseofulvin and its glucoronide conjugateT
Excreted predominantly renallyT
For the treatment of dermatophyte infectionsT
Effective in pit versic and candidiasisF
Useful in deep mycotic infectionsF
High affinity for keratinF, low
Long term therapy 9-12 months is required for tinea of the nailsT
Effective in tinea capitisT
Doses > 20mg/kg/day are increasingly effectiveF - above this level, probably no significant differences
Should be taken fastingF - can be pulverised and taken with food
Useful in tinea imbricataT
Periodic renal, hepatic and haemotpoietic functions should be assessedT
Risk of conjoined twins if used in pregnancyT
Dosing for tinea capitis is 15-30mg/kg/day for microsize or 8-17mg/kg/day for ultramicrosize for 6-8 weeksT
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